Results 41 to 50 of about 140,675 (264)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Repetition rate tunable single-longitudinal-mode acoustic-optical Q-switched nanosecond laser

Results in Physics, 2023
Repetition rate-tunable single-longitudinal-mode (SLM) lasers are in wide demand for light detection and ranging. This study proposes an SLM acoustic-optical Q-switched Nd:YVO4 laser based on a short-cavity scheme.
Yifu Chen, Zhenxu Bai, Duo Jin, Yindong Li, Yaoyao Qi, Jie Ding, Bingzheng Yan, Kun Wang, Yulei Wang, Zhiwei Lu   +9 more
doaj   +1 more source

Wavelength-tunable single longitudinal mode fiber optical parametric oscillator

Optics Express, 2017
We demonstrate a ring cavity single longitudinal mode fiber optical parametric oscillator using a passive sub-ring cavity and an unpumped erbium doped fiber configured with an external fiber mirror for single mode selection. The unpumped erbium doped fiber uses its saturable absorption characteristic to generate a self-induced narrowband filter when ...
L. T. Lim, M. H. Abu Bakar, Mohd Adzir Mahdi   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Direct generation of genuine single-longitudinal-mode narrowband photon pairs

New Journal of Physics, 2015
The practical prospect of quantum communication and information processing relies on sophisticated single-photon pairs, which feature a controllable waveform, narrow spectrum, excellent purity, fiber compatibility, and miniaturized design.
Kai-Hong Luo, Harald Herrmann, Stephan Krapick, Benjamin Brecht, Raimund Ricken, Viktor Quiring, Hubertus Suche, Wolfgang Sohler, Christine Silberhorn   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Wavelength-Spacing Switchable Dual-Wavelength Single Longitudinal Mode Thulium-Doped Fiber Laser at 1.9 μm

IEEE Photonics Journal, 2016
We propose and demonstrate a spacing switchable dual-wavelength single longitudinal mode thulium-doped fiber laser at 1.9 μm. The fiber laser employs a ring cavity and a segment of 4-m thulium-doped fiber pumped by a 1563 nm laser. A
Wanzhuo Ma, Tianshu Wang, Yuwei Su, Yan Zhang, Peng Liu, Qingsong Jia, Peng Zhang, Huilin Jiang   +7 more
doaj   +1 more source

Wavelength-Switchable Single-Longitudinal- Mode Thulium-Doped Fiber Laser With Sampled Fiber Bragg Grating

IEEE Access, 2021
A wavelength-switchable single-longitudinal-mode thulium-doped fiber laser using a sampled fiber Bragg grating is proposed in this study. The laser can be switched between three single-wavelength and three dual-wavelength modes of operation.
Wenguo Han, Fengping Yan, Ting Feng, Luna Zhang, Biao Guan, Qi Qin, Ying Guo, Ting Li, Hong Zhou, Yuping Suo   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High Q Lateral-Field-Excited Bulk Resonator Based on Single-Crystal LiTaO₃ for 5G Wireless Communication

IEEE Journal of the Electron Devices Society, 2021
The paper presents the design and fabrication of lateral-field-excited (LFE) resonators based on 42° Y-cut single-crystal LiTaO3 (LT) on silicon dioxide (SiO2).
Yanmei Xue, Xiaodong Yang, Changjian Zhou, Xiu Yin Zhang, Mansun Chan   +4 more
doaj   +1 more source