Results 51 to 60 of about 140,675 (264)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Tunable Narrow Linewidth Erbium-Doped Fiber Ring Laser Based on Saturable Absorber and Self-Injection Feedback

IEEE Photonics Journal
We demonstrate a tunable single-longitudinal-mode (SLM) narrow linewidth erbium-doped fiber (EDF) ring laser (EDFRL) in a cost-effective way. The laser incorporates an unpumped-EDF-based saturable absorber (SA) and a self-injection feedback loop for mode
Fujun Xu, Xiaxiao Wang, Xiaobin Xu, Ningfang Song   +3 more
doaj   +1 more source

Longitudinal mode-coupling instabilities of proton bunches in the CERN Super Proton Synchrotron

Physical Review Accelerators and Beams, 2023
In this paper, we study single-bunch instabilities observed in the CERN Super Proton Synchrotron (SPS). According to the linearized Vlasov theory, radial or azimuthal mode-coupling instabilities result from a coupling of bunch-oscillation modes, which ...
Ivan Karpov
doaj   +1 more source

Impact of Mode Switching on Nonresponse and Bias in a Multimode Longitudinal Study of Young Adults

Survey Research Methods, 2023
Young adults are generally hard to survey, presenting researchers with numerous difficulties. They are hard to locate and contact due to high mobility. They are hard to persuade and exhibit high levels of resistance to survey participation. As a result,
Ting Yan, Jonathan Wivagg, William Young, Cristine Delnevo, Daniel Gundersen   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Compound four-cavity single-longitudinal mode fiber laser

Optics Express
A compound resonant cavity-type single longitudinal mode erbium-doped fiber laser is proposed and verified in this paper. We use a compound four-cavity to expand the longitudinal mode spacing of the laser and a homemade grating F-P filter and a saturable absorber to narrow the gain spectral bandwidth, enabling the laser to operate in a single-frequency
Huiping, Chen, Jun, Yang, Shuxiang, Song, Biao, Long   +3 more
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Single-longitudinal-mode tunable WDM-channel-selectable fiber laser

Optics Express, 2002
We report operation of a single-longitudinal-mode WDMchannel-selectable fiber laser. The use of a tunable fiber Bragg grating and a linewidth narrowing saturable absorption filter in conjunction with an intracavity etalon enabled single-frequency emission and discretely tunable WDM channel operation without the need for external wavelength locking ...
Nathaniel, Libatique, Li, Wang, Ravi, Jain   +2 more
openaire   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source