Results 71 to 80 of about 7,974,684 (289)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Cailiao gongcheng, 2020 At the conditions of 760℃/800 MPa, 980℃/250 MPa and 1100℃/137 MPa, the transv-erse stress rupture properties of a nickel-based third generation single crystal superalloy were investigated.
YANG Wan-peng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
On the experience and evidence about mixing modes of data collection in large-scale surveys where the web is used as one of the modes in data collection [PDF]
, 2011 This paper presents experience and evidence, from international sources, of the effects on survey quality of the use of mixed modes in data collection, where the web is used as one of the modes.
Gumy, Julia M +3 more
core
Single-photon circularly polarized single-mode vortex beams
, 2023 Generation of single photons carrying spin and orbital angular momenta (SAM and OAM) opens enticing perspectives for exploiting multiple degrees of freedom for high-dimensional quantum systems.
Changying Zhao (5990135) +5 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Inverse scattering designs of dispersion-engineered single-mode planar waveguides
We use an inverse-scattering (IS) approach to design single-mode waveguides with controlled linear and higher-order dispersion. The technique is based on a numerical solution to the Gelfand-Levitan-Marchenko integral equation, for the inversion of ...
Poletti, F., May, A.R., Zervas, M.N.
core +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Quasi-single mode operated few-mode fiber for distributed acoustic sensing
, 2019 We experimentally report a proof-of-concept demonstration of a few-mode fiber (FMF) based distributed acoustic sensor (DAS) design, aiming at upgrading the capabilities of the typical DAS that employs the standard single mode fiber (SMF).
Frode Hveding +11 more
core +1 more source