Results 171 to 180 of about 5,402,175 (290)

An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics. [PDF]

Nat Commun, 2023
Hartmann A, Hartmann A, Sreenivasa K, Schenkel M, Chamachi N, Schake P, Krainer G, Schlierf M.   +7 more
europepmc   +1 more source

Stretchable, Tough, and Luminescent Perovskite Molecular Ferroelectric Composite: Empowering Reliable Self‐Powered Motion Sensing in High Humidity and Subzero Temperatures

Advanced Science, EarlyView.
A flexible molecular ferroelectric composite is fabricated via in situ growth of luminescent DMAA‐MnCl3 ferroelectric crystals within a SEBS/SIS double‐polymer matrix. It delivers 7.54 MPa tensile strength, over 1200% tensile strain, durable piezoelectric motion sensing, and excellent harsh‐environment stability for all‐weather wearable biomechanical ...
Shuangqing Li, Zhe‐Kun Xu, Zheng Xing, Jin‐Wang Liu, Yong‐Quan Wu, Peng‐Fei Li, Zhong‐Xia Wang   +6 more
wiley   +1 more source

Single-Molecule FRET-Tracking of InlB-Activated MET Receptors in Living Cells. [PDF]

Small
Li Y, Dietz MS, Barth HD, Niemann HH, Heilemann M.   +4 more
europepmc   +1 more source

Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs. [PDF]

Nucleic Acids Res, 2023
Hou Q, Chatterjee S, Lund PE, Suddala KC, Walter NG.   +4 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Simulating Freely Diffusing Single-Molecule FRET Data with Consideration of Protein Conformational Dynamics. [PDF]

J Phys Chem B
Losey J, Jauch M, Cortes-Cubero A, Wu H, Polasa A, Sauve S, Rivera R, Matteson DS, Moradi M.   +8 more
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRET. [PDF]

Protein Sci
Higinbotham HR, Arbour CA, Imperiali B.
europepmc   +1 more source

Can DyeCycling break the photobleaching limit in single-molecule FRET? [PDF]

Nano Res, 2022
Vermeer B, Schmid S.
europepmc   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source