Results 11 to 20 of about 724,526 (380)

Genetic epidemiology of single-nucleotide polymorphisms [PDF]

Proceedings of the National Academy of Sciences, 1999
On the causal hypothesis, most genetic determinants of disease are single-nucleotide polymorphisms (SNPs) that are likely to be selected as markers for positional cloning. On the proximity hypothesis, most disease determinants will not be included among markers but may be detected through linkage disequilibrium with other SNPs.
Andrew Collins, Christine Lonjou, Newton E. Morton   +2 more
openalex   +5 more sources

Electrophoretic Detection of Single-Nucleotide Polymorphisms [PDF]

BioTechniques, 2000
Single-nucleotide polymorphisms (SNPs) represent the most prevalent class of genetic markers available for linkage disequilibrium or cladistic analyses. PCR primers may be labeled with fluorescent dyes and used to rapidly and accurately differentiate among alleles that are defined by a single-nucleotide differences.
Deven R. See, Vladimir Kanazin, Hope Talbert, Tom Blake   +3 more
openalex   +5 more sources

Flow Cytometric Platform for High-Throughput Single Nucleotide Polymorphism Analysis [PDF]

BioTechniques, 2001
We have developed a rapid, cost-effective, high-throughput readout for single nucleotide polymorphism (SNP) genotyping using flow cytometric analysis performed on a Luminex™ 100 flow cytometer.
J.D. Taylor, D. Briley, Q. Nguyen, K. Long, M.A. Iannone, M.-S. Li, F. Ye, A. Afshari, E. Lai, M. Wagner, J. Chen, M.P. Weiner   +11 more
doaj   +2 more sources

Single Nucleotide Polymorphism

Definitions, 2020
A. Willsey, M. Morris
semanticscholar   +4 more sources

Detection of Single-Nucleotide Polymorphism

BioTechniques, 1998
Weikuan Gu, Gustavo D. Aguirre, Kunal Ray   +2 more
doaj   +4 more sources

Investigations into the Molecular Effects of Single Nucleotide Polymorphism [PDF]

, 2000
Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Horst D. Lohrer, Uwe Tangen
openalex   +4 more sources

TMPRSS2 gene, single nucleotide polymorphism rs8134378, single nucleotide polymorphism rs12329760.

Syrian Journal for Science and Innovation, 2023
Since the spread of the COVID-19 pandemic, there has been a variation in the prevalence rates of the coronavirus that causes the disease, the distribution of moderate and severe symptoms, and death rates, among different populations.
Majd Aljamali , Lama Youssef
doaj   +1 more source

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation

Science, 2022
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase (IDH)–mutant low-grade glioma (LGG)
C. Yanchus, K. Drucker, T. Kollmeyer, R. Tsai, M. Liang, L. Jiang, J. Pawling, A. Ali, P. Decker, M. Kosel, A. Panda, A. Malik, K. Al-Zahrani, J. Hernandez, M. Ahmed, S. Loganathan, D. Trcka, A. Michaelraj, J. Fortin, P. Mazrooei, L. Zhou, A. Elia, M. Lupien, H. He, L. Wang, A. Abyzov, J. Dennis, M. Wilson, J. Wrana, D. Lachance, M. Wrensch, J. Wienck, L. Pennacchio, D. Dickel, A. Visel, M. Taylor, G. Zadeh, P. Dirks, J. E. Eckel Passow, T. Mak, E. Kvon, R. Jenkins, D. Schramek   +42 more
semanticscholar   +1 more source

Single-Nucleotide Polymorphisms in Soybean [PDF]

Genetics, 2003
Abstract Single-nucleotide polymorphisms (SNPs) provide an abundant source of DNA polymorphisms in a number of eukaryotic species. Information on the frequency, nature, and distribution of SNPs in plant genomes is limited. Thus, our objectives were (1) to determine SNP frequency in coding and noncoding soybean (Glycine max L.
Perry B. Cregan, David L. Hyten, Qijian Song, Qijian Song, S. M. Hyatt, Lakshmi K. Matukumalli, Lakshmi K. Matukumalli, Edward W. Fickus, Youlin Zhu, Youlin Zhu, Nevin D. Young, Dirk Grimm, C.P. Van Tassell   +12 more
openaire   +3 more sources

Detection of Single Nucleotide Polymorphisms [PDF]

Current Issues in Molecular Biology, 2003
Single nucleotide polymorphism (SNP) detection technologies are used to scan for new polymorphisms and to determine the allele(s) of a known polymorphism in target sequences. SNP detection technologies have evolved from labor intensive, time consuming, and expensive processes to some of the most highly automated, efficient, and relatively inexpensive ...
Kwok, Pui-Yan, Chen, Xiangning
openaire   +3 more sources