Results 271 to 280 of about 724,526 (380)
Model‐Based Optimization of Fed‐Batch In Vitro Transcription
ChemBioChem, EarlyView.Using a mathematical model for the enzyme kinetics and solution thermodynamics of the in vitro transcription reaction, new optimized strategies are developed for fed‐batch transcription that can decrease the resource costs of mRNA synthesis while maintaining critical quality attributes for efficacy in vivo.
Nathan Merica Stover +5 more
wiley +1 more source
Association Between Single-Nucleotide Polymorphism rs2287886 of <i>CD209</i> Gene and Clinical Severity of COVID-19 in Unvaccinated Brazilian Patients. [PDF]
Genes (Basel)Galisa SLG +13 more
europepmc +1 more source
Targeting Cryptochromes in Chronic Diseases
Cell Biology International, EarlyView.ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley +1 more source
Role of single-nucleotide polymorphism microarray in the classification of BAP1-inactivated melanocytic tumours. [PDF]
HistopathologyDurgin JS +9 more
europepmc +1 more source
HLA-J, A SECOND INACTIVATED CLASS I HLA GENE RELATED TO HLA-G AND HLA-A [PDF]
, 1992 Girdlestone, J. +5 more
core +1 more source
Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li +4 more
wiley +1 more source
Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications
Chemistry – A European Journal, EarlyView.Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju +4 more
wiley +1 more source
Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS
Clinical Pharmacology &Therapeutics, EarlyView.Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenomics enables the personalization of drug therapy by linking genetic variations to differences in drug metabolism, efficacy, and risk of adverse reactions. Genetic polymorphisms within cytochrome P450 (CYP) genes significantly affect enzyme activity, influencing drug plasma levels, responses, and safety.
Alex J. Coulter +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon +18 more
wiley +1 more source