Results 281 to 290 of about 724,526 (380)

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans. [PDF]

Front Pharmacol
Park JW, Kim JM, Bang YY, Kim KA, Yu S, Park JY.   +5 more
europepmc   +1 more source

Transforming Pharmacovigilance With Pharmacogenomics: Toward Personalized Risk Management

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is a critical component of medication safety. Despite rigorous evaluation of new drugs during clinical trials, some adverse effects might only be identified once pharmaceuticals are used by a larger population for a longer duration.
Claire Spahn, Nanase Toda, Blaine Groat, Omar Aimer, Sara Rogers, Akinyemi Oni‐Orisan, Andrew Monte, Nancy Hakooz, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +8 more
wiley   +1 more source

Analysis of ABCG2 gene rs2231142 single nucleotide polymorphism and risk factors in hyperuricemia. [PDF]

Sci Rep
Liang M, Liu X, Sun M, Zhu J, Yang S, Jing F, Shen J, He Y, Chen W, Sun Y, Li Y.   +10 more
europepmc   +1 more source

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

Journal of Immunology, 2012
Irini Evnouchidou, J. Birtley, S. Seregin, A. Papakyriakou, E. Zervoudi, M. Samiotaki, G. Panayotou, P. Giastas, Olivia Petrakis, D. Georgiadis, A. Amalfitano, E. Saridakis, I. Mavridis, E. Stratikos   +13 more
semanticscholar   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population. [PDF]

BMC Cardiovasc Disord
Wang D, Liu W, Wang L, Zhang N, Huang X, Chen H.   +5 more
europepmc   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

A retrospective single center analysis of fetuses with region of homozygosity detected by single nucleotide polymorphism array. [PDF]

Sci Rep
Bu X, Yu X, Zeng L, Zeng G, Tan R, Peng C, Zhou S, Linpeng S, Liu J.   +8 more
europepmc   +1 more source

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang, M. A. Magateshvaren Saras, K. Conn, E. Greaves, F. Reed, S. Tyagi, H. Munguba, C. J. Foldi   +7 more
wiley   +1 more source

Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure. [PDF]

J Hypertens
Lidani KCF, Tomar S, Mousavi H, Buscaglia R, Michael K, Landry AP, Dupuis L, Michos ED, Morgan ES, Guo X, Yao J, Lin HJ, Rotter JI, Post WS, Tsimikas S, Trainor PJ, DeFilippis AP.   +16 more
europepmc   +1 more source