Results 291 to 300 of about 260,369 (317)
Some of the next articles are maybe not open access.
Single Nucleotide Polymorphisms (SNPs)
2014Single nucleotide polymorphisms (SNPs) have been suggested as a useful tool for dissecting various human complex disorders, classically at a small scale and recently at large genome-wide levels. The advent of new technologies, including chip-based genotyping as well as high-throughput next generation sequencing, has opened new avenues for SNPs to be ...
Batra, Jyotsna +2 more
openaire +3 more sources
Cytokine Single Nucleotide Polymorphisms in Iran
Journal of Interferon & Cytokine Research, 2006Overall expression and secretion of cytokines are dependent on genetic nucleotide variations within or adjacent to regulatory regions of cytokine genes. This study allows the comparison of the prevalence of particular genetic markers. In 40 Iranian healthy subjects, cytokine single nucleotide polymorphisms (SNPs) were used to determine allelic and ...
Davood Omrani +2 more
openaire +3 more sources
Single-Nucleotide Polymorphism Analysis by Pyrosequencing
Analytical Biochemistry, 2000There is a growing demand for high-throughput methods for analysis of single-nucleotide polymorphic (SNP) positions. Here, we have evaluated a novel sequencing approach, pyrosequencing, for such purposes. Pyrosequencing is a sequencing-by-synthesis method in which a cascade of enzymatic reactions yields detectable light, which is proportional to ...
Baback Gharizadeh +6 more
openaire +3 more sources
Single nucleotide polymorphism hunting in cyberspace
Human Mutation, 1998Large-scale sequencing of human cDNA and genomic DNA libraries has produced a large collection of sequence data in public databases. To date, >900,000 human expressed sequence tag (EST) sequences and >80,000,000 bases of genomic DNA sequence have been deposited in Genbank.
Pui-Yan Kwok +2 more
openaire +3 more sources
Genotyping of Single Nucleotide Polymorphisms
2015Single nucleotide polymorphisms (SNPs) are the most abundant DNA variations in human genome. Numerous reports have indicated that SNPs are closely associated with diseases such as cardiovascular diseases, different types of cancer, and other genetic diseases.
Tian Ye, Ran Tong, Zhiqiang Gao
openaire +2 more sources
Single nucleotide polymorphisms: aging and diseases
Biogerontology, 2004Differences of more than 3 million nucleotides can bee seen comparing the genomes of two individuals as a result of single nucleotide polymorphism (SNP). More and more SNPs can be identified and it seems that these alterations are behind of several biological phenomena.
Margit Zeher +4 more
openaire +3 more sources
Single Nucleotide Polymorphisms and Their Applications
2007SNPs are highly abundant in the human genome, explaining most of sequence variation. This makes them a valuable resource for population genetics, evolution, and gene mapping. In this article we have given an overview of the major issues arising in their application to haplotype and haplotype block estimation and genetic association.
Zhaoxia Yu, Rudy Guerra
openaire +2 more sources
Shares in single nucleotide polymorphisms
Expert Opinion on Therapeutic Patents, 1999The announcement of a consortium between the public and private sectors to produce a public single nucleotide polymorphism (SNP) map of the human genome is a unique development which acknowledges the need for research tools to be widely available. The human genome project has been characterised by public-private tensions over information access and ...
openaire +2 more sources
Single Nucleotide Polymorphism Typing
2019Single nucleotide polymorphism (SNP) typing process utilizes biochemical techniques to determine the sequential order of nucleotide bases in a DNA strand using sequencing machines. Last decade has witnessed a tremendous expansion since the invention of the Sanger sequencing.
Srinivasan, Srilakshmi, Batra, Jyotsna
openaire +2 more sources
Methods for Genotyping Single Nucleotide Polymorphisms
Annual Review of Genomics and Human Genetics, 2001One of the fruits of the Human Genome Project is the discovery of millions of DNA sequence variants in the human genome. The majority of these variants are single nucleotide polymorphisms (SNPs). A dense set of SNP markers opens up the possibility of studying the genetic basis of complex diseases by population approaches.
openaire +2 more sources