Results 121 to 130 of about 6,146,275 (314)

Rapid extraction-free detection of the R132H isocitrate dehydrogenase mutation in glioma using colorimetric peptide nucleic acid-loop mediated isothermal amplification (CPNA-LAMP).

PLoS ONE, 2023
The R132H isocitrate dehydrogenase one (IDH1) mutation is a prognostic biomarker present in a subset of gliomas and is associated with heightened survival when paired with aggressive surgical resection.
Kristian A Choate, Edward J Raack, Veronica F Line, Matthew J Jennings, Robert J Belton, Robert J Winn, Paul B Mann   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single nucleotide variant types identified in MYD88, IRAK4 and IKBKG.

, 2015
aMS/NS/SS: Missense/Nonsense/Splice-siteSingle nucleotide variant types identified in MYD88, IRAK4 and IKBKG.
Katherine S. Elliott (174560), Anna Rautanen (246408), Derrick W. Crook (145636), Stephen J. Chapman (246410), Adrian V. S. Hill (40512), Magda K. Ellis (595324)   +5 more
core   +1 more source

INSIG1 influences obesity-related hypertriglyceridemia in humans [PDF]

, 2010
In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the ...
Carless, M., Blangero, J., Kissebah, A., Curran, J., Cole, R., Dyer, T. D., Curran, Joanne E., Carless, Melanie A., Olivier, M. (Michael), Dyer, T., Abraham, L., Moses, Eric, Martin, L. J. (Lisa J.), Gawrieh, S., Olivier, M., Zhang, Y., Baye, T., Smith, Edward M., Baye, T. M., Kissebah, Ahmed, Abraham, L. J., Moses, E. K. (Eric Keith), Martin, L., Smith, E.   +23 more
core   +1 more source

Assessment of Single Nucleotide Variants in hGPRC5A Gene Using in-silico Tools

, 2023
Abstract G-protein-couple receptor family C group 5 member A (GPRC5A) encodes a transmembrane protein and is induced by retinoic acid. Dysfunctional GPRC5A was reported to activate numerous signal transduction cascades and its tumor suppressor role was emphasized especially in lung cancer in recent studies.
UZ YILDIRIM, ELİF, ÇELİKLER KASIMOĞULLARI, SERAP, Demirbağ Karaali, Merve   +2 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Single-Nucleotide-Specific Lipidic Nanoflares for Precise and Visible Detection of KRAS Mutations via Toehold-Initiated Self-Priming DNA Polymerization

Accurate identification of single-nucleotide mutations in circulating tumor DNA (ctDNA) is critical for cancer surveillance and cell biology research.
Ruize Cheng (17710702), Chang Xue (1329414), Guohui Xue (9775220), Yinghao Cheng (14311281), Qiufeng Song (17710699), Jianguo Xu (12151), Zhifa Shen (1694104), Xiaoling Wei (2265049), Chan Li (433717), Haiyan Jia (224721)   +9 more
core   +1 more source

Single-nucleotide polymorphisms suggestively associated with spontaneous preterm birth.

, 2019
Single-nucleotide polymorphisms suggestively associated with spontaneous preterm birth.
Mika Rämet (133146), Antti M. Haapalainen (6836669), Louis J. Muglia (114366), Minna K. Karjalainen (114311), Riitta Marttila (6836675), Anu Pasanen (6836672), Marja Ojaniemi (230956), Mikko Hallman (114373), Heli Tiensuu (6836666), Johanna M. Huusko (114315)   +9 more
core   +1 more source