Results 121 to 130 of about 1,316,697 (275)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

On the application of differences in intrinsic fluctuations of Cherenkov light images for separation of air showers

, 2001
The sensitivity of ground-based imaging atmospheric Cherenkov gamma-ray observatories depends critically on the primary particle identification methods which are used to retain photon-initiated events and suppress the spurious background produced by ...
A.V Plyasheshnikov, Aharonian, Aharonian, Aharonian, Catanese, Galbraith, Konopelko, Ong, Plyasheshnikov, Punch, Quinn, Reynolds, T.C Weekes, Ulrich, V.V Bugayov, V.V Vassiliev, Weekes   +16 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multicolor cathodoluminescence imaging of single lanthanide nanoparticles

Nature Communications
Cathodoluminescence (CL) microscopy offers a promising approach to nanoscale analysis, enabling detection of optical emission from a sample while leveraging the high resolution of electron microscopy.
Sohaib Abdul Rehman, Jeremy B. Conway, Amy Nichols, Edward R. Soucy, Amanda Dee, Kristal Stevens, Simon Merminod, Isabella MacNaughton, Abigail Curtis, Maxim B. Prigozhin   +9 more
doaj   +1 more source

Supervised Classification Methods for Flash X-ray single particle diffraction Imaging

, 2018
Current Flash X-ray single-particle diffraction Imaging (FXI) experiments, which operate on modern X-ray Free Electron Lasers (XFELs), can record millions of interpretable diffraction patterns from individual biomolecules per day.
Engblom, Stefan, Liu, Jing, van der Schot, Gijs   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rapid single-particle chemical imaging of nanoplastics by SRS microscopy

Proceedings of the National Academy of Sciences of the United States of America
Significance Micro-nano plastics originating from the prevalent usage of plastics have raised increasingly alarming concerns worldwide. However, there remains a fundamental knowledge gap in nanoplastics because of the lack of effective analytical ...
Naixin Qian, Xin Gao, Xiaoqi Lang, Huiping Deng, Teodora Maria Bratu, Qixuan Chen, Phoebe Stapleton, Beizhan Yan, Wei Min   +8 more
semanticscholar   +1 more source

A novel type of proximity focusing RICH counter with multiple refractive index aerogel radiator

, 2005
A proximity focusing ring imaging Cherenkov detector, with the radiator consisting of two or more aerogel layers of different refractive indices, has been tested in 1-4 GeV/c pion beams at KEK.
A. Gorišek, H. Kawai, H. Konishi, I. Adachi, Iijima, Kurokawa, Matsumoto, P. Križan, R. Pestotnik, S. Fratina, S. Korpar, S. Nishida, S. Ogawa, S. Ohtake, S. Saitoh, S. Yamamoto, T. Fukushima, T. Iijima, T. Matsumoto, T. Seki, T. Sumiyoshi, Y. Kozakai, Y. Mazuka, Y. Uchida, Y. Unno   +24 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source