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Optimizing aerodynamic lenses for single-particle imaging [PDF]

open access: yesJournal of Aerosol Science, 2018
A numerical simulation infrastructure capable of calculating the flow of gas and the trajectories of particles through an aerodynamic lens injector is presented. The simulations increase the fundamental understanding and predict optimized injection geometries and parameters.
Nils Roth, Salah Awel, Daniel Horke
exaly   +6 more sources
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Single-particle imaging for biosensor applications

Emerging Imaging and Sensing Technologies for Security and Defence II, 2017
Current state-of-the-art technology for in-vitro diagnostics employ laboratory tests such as ELISA that consists of a multi-step test procedure and give results in analog format. Results of these tests are interpreted by the color change in a set of diluted samples in a multi-well plate.
Celalettin Yurdakul   +6 more
openaire   +1 more source

Single-Particle Imaging of Anion Exchange Reactions in Cuprous Oxide

ACS Nano, 2021
Ion exchange is a predominant and flexible route to tailor the composition and crystal structure of various materials. In situ monitoring of the ion exchange process at the single-particle level is critical to better understand the reaction mechanism and engineer high-performance materials.
Haili Yu, Yi He, Yongbing Zhu
exaly   +3 more sources

A minimal view of single-particle imaging with X-ray lasers [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2014
The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining the three-dimensional structure of biomolecules without crystallization. However, the complexity of imaging a sample's structure from very many of its noisy and incomplete diffraction data can be ...
N Duane Loh
exaly   +3 more sources

Single-particle imaging

2007
The current status of single-particle X-ray imaging - or "X-ray crystallography without need for a crystal" - is reviewed, with particular emphasis on the Stony Brook/Cornell/Berkeley single yeast cell imaging project. Two-dimensional (2D) images of a quick-frozen yeast cell have been obtained with a resolution which, if carried out in three ...
openaire   +1 more source

Diffractive Imaging of Single Particles

2019
The computational methods and applications of diffractive (lensless) imaging are reviewed. Far-field scattering (e. g., by neutrons, electrons, light, or x-rays) by a nonperiodic localized potential is detected and the phase problem solved using iterative optimization methods, which allows a three-dimensional image of the object potential to be ...
openaire   +1 more source

Ultrahigh-Throughput Single-Particle Hyperspectral Imaging of Gold Nanoparticles

Analytical Chemistry, 2023
Gold nanoparticles (AuNPs) have become increasingly useful in recent years for their roles in nanomedicine, cellular biology, energy storage and conversion, photocatalysis, and more. At the single-particle level, AuNPs have heterogeneous physical and chemical properties which are not resolvable in ensemble measurements.
James Ethan Batey   +3 more
openaire   +2 more sources

A Motion Transformer for Single Particle Tracking in Fluorescence Microscopy Images

2023
Abstract Single particle tracking is an important image analysis technique widely used in biomedical sciences to follow the movement of sub-cellular structures, which typically appear as individual particles in fluorescence microscopy images.
Yudong Zhang, Ge Yang
openaire   +1 more source

Optimizing and Scaling the 3D Reconstruction of Single-Particle Imaging

2024 IEEE International Parallel and Distributed Processing Symposium (IPDPS)
An X-ray free electron laser (XFEL) facility can produce on the order of 1,000,000 extremely bright X-ray light pulses per second. Using an XFEL to image the atomic structure of a molecule requires fast analysis of an enormous amount of data, estimated to exceed one terabyte per second and requiring petabytes of storage.
Niteya Shah   +4 more
openaire   +2 more sources

Single-particle tracking image microscopy.

Methods in enzymology, 2003
The techniques of single particle tracking (SPT) and optical force microscopy (OFM) as described above allow direct imaging of the motion of molecules in the membrane of live cells, and provide a means of controlling the movement by an almost noninvasive method.
Ken, Ritchie, Akihiro, Kusumi
openaire   +1 more source

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