USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Household composition across the new Europe: Where do the new Member States fit in? [PDF]
In this paper we present indicators of household structure for 26 of the 27 countries of the post-enlargement European Union. As well as broad indicators of household type, we present statistics on single-person and extended-family households, and on the
Maria Iacovou, Alexandra J. Skew
core
Factors Associated with Suicidal Ideation Among Middle-Aged Korean Adults: A Cross-Sectional Analysis of the 2022-2023 Korea National Health and Nutrition Examination Survey. [PDF]
Healthcare (Basel)Son JH, Kim CG, Hong JS, Oh YH, Choi JY.
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Socio-Economic Determinants of Care-Seeking Knowledge for Persistent Dyspeptic Symptoms in a High-Prevalence Helicobacter pylori Region. [PDF]
CureusAlamer E.
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Individuals in Household Panels: The importance of person group clustering
, 2009 In this paper: Defining / exploring the person group context - Different types of 'person group' (cf. household) - Longitudinal treatments for 'person groups' - Alternative modelling strategies - Multilevel / random effects - Other regression approaches -
Lambert, Paul, Gayle, Vernon
core
Shrinking household size and CO<sub>2</sub> emissions in China evidence from machine learning and input output models. [PDF]
iScienceYu Y, Wang H, Wang H, Huang W, Qian T.
europepmc +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source