Results 61 to 70 of about 2,116,123 (314)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Effect of sand particles on flow structure of free jet from a nozzle

open access: yesJournal of Mechanical Engineering and Sciences, 2019
The Characteristics of single and two- phase flow from a circular turbulent free jet from a nozzle of 10 mm diameter were investigated experimentally and numerically. The measurements were conducted for ReJ = 10007 - 31561.
M. J. Al-Dulaimi   +3 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Flow and heat transfer in a closed loop thermosyphon. Part I – theoretical simulation

open access: yesJournal of Energy in Southern Africa, 2017
A natural circulation, closed loop thermosyphon can transfer heat over relatively large distances without any moving parts such as pumps and active controls.
R.T. Dobson, J.C. Ruppersberg
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Assessment of MARS-KS prediction capability for natural circulation flow in passive heat removal system

open access: yesNuclear Engineering and Technology
Considering that system analysis codes are used for the evaluation of the performance of Passive Safety Systems (PSSs), it is important to investigate the capability of the system analysis code to reliably predict the heat transfer and natural ...
Jehee Lee   +4 more
doaj   +1 more source

Single well gathering and transportation process of produced fluid from high-CO2 gasfield in Huangqiao

open access: yesYou-qi chuyun, 2020
In order to efficiently recover and utilize the produced fluid from high-CO2 gas wells in Huangqiao, thermodynamic state equation (PRSV state equation and WS mixing rule) and flash evaporation calculation theory were adopted for phase state calculation ...
Kuijie REN   +5 more
doaj   +1 more source

Characterisation of Single-Phase Fluid-Flow Heterogeneity Due to Localised Deformation in a Porous Rock Using Rapid Neutron Tomography [PDF]

open access: gold, 2021
Maddi Etxegarai   +5 more
openalex   +1 more source

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