Results 81 to 90 of about 2,116,123 (314)

Numerical modeling of flow structure and heat transfer in a mist turbulent flow downstream of a pipe sudden expansion

MATEC Web of Conferences, 2016
Turbulent droplet-laden flow downstream of a sudden pipe expansion is numerically studied using Eulerian two-fluid model. The model is used to investigate the effect of droplet evaporation on the particle dispersion and on the gas phase turbulence ...
Pakhomov Maksim, Terekhov Viktor
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Direct Cooling of Microsystems Using a Two-Phase Microfluidic Droplet

Computation
Droplet-based microfluidics offers a promising approach for enhancing heat transfer in microchannels, which is critical for the thermal management of microsystems.
Wenpei Lu, Abdel Illah El Abed, Rachid Bennacer, Xiaoyan Ma   +3 more
doaj   +1 more source

Effects of Flow Regimes on Maximum Pressure in Offshore Pipelines [PDF]

مهندسی منابع آب, 2019
One of the most important factors in pipeline hydraulics and its protection against probable damages is keeping the pressure in a specific limit and also knowing how the pressure functions in the pipe through the pipeline route.
Zahra Ghadampour, Mohammad sadegh Narges
doaj  

High-flow oxygen therapy versus facemask preoxygenation in anticipated difficult airway management (PREOPTI-DAM): an open-label, single-centre, randomised controlled phase 3 trial [PDF]

, 2023
Mickaël Vourc’h, Donatien Huard, Marguerite Le Penndu, Romain Deransy, Marielle Surbled, Maelle Malidin, Pierre-Joachim Mahé, Christophe Guitton, Antoine Roquilly, O. Malard, Fanny Feuillet, Bertrand Rozec, Karim Asehnoune   +12 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research Progress of Microchannel Heat Sink Structures Based on Single-Phase Flow

Zhileng xuebao
Microchannel cooling, with its high heat transfer efficiency, low thermal resistance, and light weight advantages, is one of the most effective technologies for solving the problem of heat dissipation with high heat flux; however, it faces the issue of ...
Zhao Jie, Cui Xiaoyu
doaj  

A new deliverability evaluation method of gas condensate wells in gas–liquid two-phase state

Natural Gas Industry B, 2018
Gas well deliverability evaluation and analysis are challenging due to the frequent abnormalities of deliverability test data of gas condensate wells caused by seepage of oil and gas phases in the reservoirs.
Jialiang Lu, Hao Zhang, Baohua Chang, Wen Cao, Hedong Sun   +4 more
doaj   +1 more source