Results 91 to 100 of about 7,341,382 (291)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Analysis of predictors of clinical pregnancy and live birth in patients with RIF treated with IVF-ET technology: a cohort study based on a propensity score approach

Frontiers in Medicine
ObjectiveTo investigate the predictors of clinical pregnancy and live birth rate in patients with recurrent embryo implantation failure (RIF) treated with in vitro fertilization-embryo transfer (IVF-ET) technique.MethodThis retrospective cohort study was
Yan Jia, Yan Jia, Yan Jia, Zhonghua Ai, Xianglong Zhu, Zhuohang Che, Adhikari Pratikshya, Songyuan Tang, Qiong Zhang   +8 more
doaj   +1 more source

Advances in Embryo Transfer [PDF]

, 2012
Embryo transfer has become one of the prominent high businesses worldwide. This book updates and reviews some new developed theories and technologies in the human embryo transfer and mainly focus on discussing some encountered problems during embryo ...

core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Are there associations between clinical and embryological factors with pregnancy loss following transfer of a single euploid embryo?

Reproduction and Fertility
First-trimester pregnancy losses are commonly attributed to chromosomal abnormalities. The causes of pregnancy loss following transfer of a euploid embryo are not fully elucidated.
Beril Yuksel, Gonul Ozer, Ipek Nur Balin Duzguner, Aysu Akca, Yesim Kumtepe, Hakan Yelke, Semra Kahraman, George Liperis, Munevver Serdarogullari   +8 more
doaj   +1 more source

Morphological embryo selection: an elective single embryo transfer proposal

JBRA Assisted Reproduction, 2018
To describe a patient selection method for elective single embryo transfer (eSET), emphasizing inclusion criteria and results.This retrospective study included all cases seen in a private clinic between June 2011 and December 2016, in La Paz, Bolivia (3600 meters above sea level).
Déniz, Francisco Parera, Encinas, Carlos, Fuente, Jorge La   +2 more
openaire   +3 more sources

Early blastulation (EB) of day 4 embryo is predictive of outcomes in single embryo transfer (SET) cycles

, 2018
Objective: The aim of this study was to assess whether the early blastulation (EB) of day 4 embryo is a useful predictor for outcomes in fresh elective single embryo transfer (eSET) cycles.
Robert Kuo-Kuang Lee, Shyr-Yeu Lin, Yuh-Ming Hwu, Cheng-En Hsieh, Ming-Huei Lin, Fang-Ju Sun, Ryh-Sheng Li   +6 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Frozen-thawed double cleavage-stage or frozen-thawed single day 6 blastocyst stage embryo transfer: which is preferable for patients younger than 35 without day 5 blastocyst formation?

Frontiers in Endocrinology
BackgroundTo compare the clinical outcomes between frozen-thawed cleavage embryo transfer and frozen-thawed day 6 blastocyst transfer in patients younger than 35 using the freeze-all strategy without day 5 blastocyst formation.MethodsThis was a ...
Yan Liu, Yan Liu, Taojun Wang, Taojun Wang, Shanjun Dai, Shanjun Dai, Hao Shi, Hao Shi, Yingpu Sun, Yingpu Sun   +9 more
doaj   +1 more source

Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials

, 2010
To compare the effectiveness of elective single embryo transfer versus double embryo transfer on the outcomes of live birth, multiple live birth, miscarriage, preterm birth, term singleton birth, and low birth weight after fresh embryo transfer, and on ...
Harrild, K, van Montfoort, A P A, van Peperstraten, A M, McLernon, D J, de Neubourg, D, Van Royen, E, Bhattacharya, S, Davies, M J, Thurin-Kjellberg, Ann,, Dumoulin, J C M, Mol, B W, Gerris, J, Norman, R J, Martikainen, H, Tiitinen, A, Kremer, J A M, Bergh, Christina,   +16 more
core