Results 81 to 90 of about 7,341,382 (291)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Elective single embryo transfer versus double embryo transfer in assisted reproduction

Reproductive BioMedicine Online, 2008
High numbers of embryos transferred during assisted reproduction have become implicated as the cause of higher than normal twinning and multiple gestation rates following this form of therapy. However, reducing the number to a single embryo transferred has been shown to carry unfavourable results in the first cycle, but with similar cumulative live ...
Mohamed Khaled, Moustafa, Sheded Ashour, Sheded, Mohamed Abd, El Aziz Mousta   +2 more
openaire   +2 more sources

Single blastocyst embryo transfer maintains comparable pregnancy rates to double cleavage-stage embryo transfer but results in healthier pregnancy outcomes

, 2011
Background: The optimal outcome after IVF is a live, healthy, singleton term baby. This can be achieved by transferring a single embryo, but at the possible expense of reducing pregnancy rates.
Zander-Fox, D., Deirdre L. ZANDER-FOX, Kelton TREMELLEN, Michelle LANE, Tremellen, K., Lane, M.   +5 more
core   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Endometrial injury may increase the clinical pregnancy rate in normoresponders undergoing long agonist protocol ICSI cycles with single embryo transfer

, 2014
Objective: To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo ...
KART, CAVİT, YULUĞ, ESİN, YILDIRIM, Ozkan, Odaci, ERSAN, UNSAL, Mesut A., GÜVEN, SÜLEYMAN   +5 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles

Taiwanese Journal of Obstetrics & Gynecology, 2018
Objective: It is known that embryos with faster growing potential, especially in blastocyst development, correlate with the increased euploid rate. Our study investigated the preimplantation genetic screening cycle to analyze the correlation between ...
Tzu-Yu Hung, Robert Kuo-Kuang Lee, Yuh-Ming Hwu, Ming-Huei Lin, Ryh-Sheng Li, Yu-Wen Weng   +5 more
doaj   +1 more source

Embryo Transfer for the Practitioner

, 1980
The advent of "on-farm" embryo transfer has provided the opportunity for practicing veterinarians to become involved. Embryo transfer, under the direct supervision of a practicing veterinarian, has become an important part of many breeders\u27 ...
Mapletoft, Reuben J.
core   +1 more source