Results 21 to 30 of about 7,974,201 (245)
ibegleris/Single-mode-FOPO: First public release
, 2017 <p>This code simulates a single mode Fibre Optical Parametric Oscillator using Python 3.6. The theory regarding the project has been presented and shown in Numerical Simulations of Optoelectronic Devices Copenhagen 2017 and Frontiers In optics ...
Peter Horak +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Nonlinear longitudinal/transversal modal interactions in highly extensible suspended cables [PDF]
, 2008 Recent research literature mostly deals with nonlinear resonant dynamics of low-extensible cables involving transversal modes. Herein, we aim to investigate geometrically nonlinear longitudinal/transversal modal interactions in highly extensible ...
Rega, G., Srinil, N.
core +4 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Non-astigmatic Alexandrite ring laser design with wavelength-tunable single-longitudinal-mode operation [PDF]
, 2020 This work presents a study of a fully nonastigmatic design of a single-longitudinal-mode, wavelength-tunable, unidirectional alexandrite ring laser cavity and assessment of its performance compared to more complex laser design requiring astigmatism ...
Sheng, xin +4 more
core +1 more source
Single-longitudinal-mode condition for DFB lasers
Electronics Letters, 1985 We show theoretically that the loss difference of about 10% is required between the main mode and the side mode for a semiconductor laser to oscillate in single-longitudinal mode. The DFB laser has been found to meet this requirement, and a side-mode suppression of more than 30 dB was observed under high-speed direct modulation.
G. Motosugi, Y. Yoshikuni, T. Ikegami
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source