Results 111 to 120 of about 6,472,690 (313)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nature CommunicationsBiomolecular condensates, formed by liquid–liquid phase separation, coordinate key cellular activities. Recent work has revealed the role of sub-micron assemblies, or nanocondensates, in the organisation of a significant portion of the proteome. Here, we
Justin Houx +4 more
doaj +1 more source
Spontaneous signal generation by an excitable system for cell migration
Frontiers in Cell and Developmental BiologyEukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis.
Satomi Matsuoka +8 more
doaj +1 more source
Nature Communications, 2018 Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear.
Ewoud B. Compeer +15 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Surface plasmon driven atomic migration mediated by molecular monolayer
PhotoniXHighly efficient controlling the individual atomic migration is the basis of the modern atomic manufacturing. Although one-by-one atom migration can be realized precisely by STM technique, such a delicate operation is time consuming and restrictive ...
Qihong Hu +7 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Single Molecule Force Extension Measurement on Semi-Flexible Biopolymers Using Magnetic Tweezers [PDF]
, 2010 Polymers are pervasive in modern society and are commonly encountered in a wide-range of industrial processes. Polymer chains exhibit complex dynamical phenomena in solutions undergoing convective transport, and a proper understanding of chain dynamics ...
Kim, Sun Ju
core
Microscopic simulation of membrane molecule diffusion on corralled membrane surfaces [PDF]
, 2008 The current understanding of how receptors diffuse and cluster in the plasma membrane is limited. Data from single-particle tracking and laser tweezer experiments have suggested that membrane molecule diffusion is affected by the presence of barriers ...
Edwards, Jeremy S. +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source