Results 111 to 120 of about 1,178,188 (315)

Binding dynamics of a monomeric SSB protein to DNA : a single-molecule multi-process approach

, 2015
People Programme of the European Union’s Seventh Framework Programme [REA 334496 to B.E.B.]; Leonardo da Vinci European Union Programme (to M.F.G.); Wellcome Trust [099149/Z/12/Z, 091825/Z/10/Z]. Funding for open access charge: Wellcome Trust; University
J. Carlos Penedo, Maria Figueira-gonzalez, White, Malcolm F, Ackermann, Katrin, Katrin Ackermann, Penedo, Carlos, Peregrina, Jose Ramon, Bode, Bela Ernest, Michael J. Morten, Figueira-Gonzalez, Maria, Malcolm F. White, Bela E. Bode, Morten, Michael John, Jose R. Peregrina   +13 more
core   +1 more source

Circularly polarized luminescence in the one-dimensional assembly of binaphtyl-based Yb( iii ) single-molecule magnets

, 2023
Lanthanide ions have attracted great interest owing to their optical and magnetic properties. Single-molecule magnet (SMM) behavior has been a fascinating science for thirty years. Moreover, chiral lanthanide complexes allow the observation of remarkable
POINTILLART, Fabrice, LALLI, Claudia, LE GUENNIC, Boris, LEFEUVRE, Bertrand, GUYOT, Yannick, RIOBÉ, François, GUY, Stéphan, MONTIGAUD, Vincent, ARGOUARCH, Gilles, MAURY, Olivier, DORCET, Vincent, MATTEI, Carlo Andrea, CADOR, Olivier, BENSALAH-LEDOUX, Amina, GINDRE, Cyprien, BAGUENARD, Bruno   +15 more
core   +1 more source

Direct observation and quantification of single nanocondensates of the low complexity domain of TDP-43

Nature Communications
Biomolecular condensates, formed by liquid–liquid phase separation, coordinate key cellular activities. Recent work has revealed the role of sub-micron assemblies, or nanocondensates, in the organisation of a significant portion of the proteome. Here, we
Justin Houx, Julian Cussac, Thomas Copie, Yann Gambin, Emma Sierecki   +4 more
doaj   +1 more source

Spontaneous signal generation by an excitable system for cell migration

Frontiers in Cell and Developmental Biology
Eukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis.
Satomi Matsuoka, Satomi Matsuoka, Satomi Matsuoka, Koji Iwamoto, Da Young Shin, Da Young Shin, Masahiro Ueda, Masahiro Ueda, Masahiro Ueda   +8 more
doaj   +1 more source

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

Nature Communications, 2018
Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear.
Ewoud B. Compeer, Felix Kraus, Manuela Ecker, Gregory Redpath, Mayan Amiezer, Nils Rother, Philip R. Nicovich, Natasha Kapoor-Kaushik, Qiji Deng, Guerric P. B. Samson, Zhengmin Yang, Jieqiong Lou, Michael Carnell, Haig Vartoukian, Katharina Gaus, Jérémie Rossy   +15 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Surface plasmon driven atomic migration mediated by molecular monolayer

PhotoniX
Highly efficient controlling the individual atomic migration is the basis of the modern atomic manufacturing. Although one-by-one atom migration can be realized precisely by STM technique, such a delicate operation is time consuming and restrictive ...
Qihong Hu, Jieyi Zhang, Ramya Emusani, Junchao Yang, Xin Zuo, Yiran Wang, Yonggang Huang, Dong Xiang   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Single-Molecule-Magnet Behavior and Fluorescence Properties of 8‑Hydroxyquinolinate Derivative-Based Rare-Earth Complexes

, 2016
Five tetranuclear rare-earth complexes, [RE4(dbm)4L6(μ3-OH)2] [HL = 5- (4-fluorobenzylidene)-8-hydroxylquinoline; dbm = 1,3-diphenyl-1,3-propanedione; RE = Y (1), Eu (2), Tb (3), Dy (4), Lu (5)], have been synthesized and completely characterized.
Hong-Ling Gao (836220), Shi-Yu Wang (836217), Hong-Xia Zhang (409783), Li Jiang (120930), Jian-Zhong Cui (836221), Wen-Min Wang (331964)   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source