Results 11 to 20 of about 10,451,032 (401)
Single-Molecule Nanomagnets [PDF]
Annual Review of Condensed Matter Physics, 2010 Single-molecule magnets straddle the classical and quantum mechanical worlds, displaying many fascinating phenomena. They may have important technological applications in information storage and quantum computation. We review the physical properties of two prototypical molecular nanomagnets, Mn12-acetate and Fe8: Each behaves as a rigid, spin-10 ...
Friedman, Jonathan R. +1 more
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Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein
Communications Biology, 2021 To better understand the specific cascade of protein interactions that lead to the pathological aggregation of α-synuclein (wild-type and mutant forms), Leitão et al.
André D. G. Leitão +7 more
doaj +1 more source
Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2
Nature Communications, 2022 Single-molecule FRET measurements provide detailed insights into the conformational states and dynamics of human Argonaute 2 that are required for its function at the core of the eukaryotic RNA silencing pathway.
Sarah Willkomm +6 more
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Single‐molecule genomics [PDF]
The Journal of Pathology, 2009 AbstractThe term ‘single‐molecule genomics’ (SMG) describes a group of molecular methods in which single molecules are detected or sequenced. The focus on the analysis of individual molecules distinguishes these techniques from more traditional methods, in which template DNA is cloned or PCR‐amplified prior to analysis. Although technically challenging,
Frank, McCaughan, Paul H, Dear
openaire +2 more sources
BMC Biology, 2018 Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll +11 more
doaj +1 more source
Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
Nature Communications, 2023 Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro +5 more
doaj +1 more source
Spontaneous Confinement of mRNA Molecules at Biomolecular Condensate Boundaries
Cells, 2023 Cellular biomolecular condensates, termed ribonucleoprotein (RNP) granules, are often enriched in messenger RNA (mRNA) molecules relative to the surrounding cytoplasm.
Rebecca T. Perelman +3 more
doaj +1 more source
Accurate detection of complex structural variations using single molecule sequencing
Nature Methods, 2017 Structural variations are the greatest source of genetic variation, but they remain poorly understood because of technological limitations. Single-molecule long-read sequencing has the potential to dramatically advance the field, although high error ...
F. Sedlazeck +6 more
semanticscholar +1 more source
De novo assembly of the cattle reference genome with single-molecule sequencing
GigaScience, 2020 Background Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10–12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated ...
B. Rosen +32 more
semanticscholar +1 more source
Single-molecule visualisation of DNA G-quadruplex formation in live cells
Nature Chemistry, 2020 Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is coupled to altered gene expression. However, approaches that allow us to probe G4s in living cells without perturbing their folding dynamics are required to ...
M. Di Antonio +10 more
semanticscholar +1 more source