Results 261 to 270 of about 1,178,188 (315)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Single-molecule mechanostructural fingerprinting of nucleic acid conformations. [PDF]

Nucleic Acids Res
Shrestha P, Bergal HT, Shih WM, Wong WP.
europepmc   +1 more source

Bridging single-molecule and genome-wide studies of cellular mRNA translation. [PDF]

RNA
Koch A, Tomuro K, Wakigawa T, Morisaki T, Iwasaki S, Stasevich TJ.   +5 more
europepmc   +1 more source

Characterizing the Impact of Nucleoid-Associated Proteins on HU-DNA Interactions by Live-Cell Single-Molecule Tracking. [PDF]

Chemphyschem
Fuller DEH, Dai X, McCarthy LA, Way LE, Wang X, Biteen JS.   +5 more
europepmc   +1 more source

Single-molecule readout of reversible nanoswitches enables continuous monitoring of low biomarker concentrations. [PDF]

Nat Commun
Vu C, Janssen SAJ, de Jong AM, Prins MWJ.   +3 more
europepmc   +1 more source

Contrasting single-molecule magnet behaviour in dysprosium and terbium bis(stannolediide) complexes. [PDF]

Nat Chem
Sun X, Hinz A, Maier S, Gillhuber S, Jin D, Saito M, Weigend F, Schlittenhardt S, Moreno-Pineda E, Wernsdorfer W, Ruben M, Roesky PW.   +11 more
europepmc   +1 more source

Current trends and challenges in deciphering single molecule resolution maps of single cell transcriptomes. [PDF]

Brief Bioinform
Schaeper D, Chowdhury U, Janga SC.
europepmc   +1 more source

Digital-micromirror-device-based illumination strategies for background suppression in single-molecule localization microscopy. [PDF]

Biomed Opt Express
Yao J, Zhang J, Xu M, Wang C, Ma D.
europepmc   +1 more source

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SINGLE-MOLECULE SPECTROSCOPY

Annual Review of Physical Chemistry, 1997
▪ Abstract  Recent experimental and theoretical studies concerning single-molecule spectroscopy in solids are discussed. Pure quantum effects—such as photon bunching, antibunching, and spectral jumps—and more classical phenomena—such as near-field excitation, saturation, ac/dc Stark shifts, spectral diffusion, two-photon excitation, and customary ...
Plakhotnik, T, Donley, EA, Wild, UP
openaire   +6 more sources

Combining single-molecule manipulation and single-molecule detection

Current Opinion in Structural Biology, 2014
Single molecule force manipulation combined with fluorescence techniques offers much promise in revealing mechanistic details of biomolecular machinery. Here, we review force-fluorescence microscopy, which combines the best features of manipulation and detection techniques.
Juan Carlos, Cordova, Dibyendu Kumar, Das, Harris W, Manning, Matthew J, Lang   +3 more
openaire   +2 more sources