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Single molecule nanobioscience
Trends in Biochemical Sciences, 2001In recent years, the rapid development and progress of single-molecule detection techniques have opened up a new era of biological research. The advantage of single-molecule studies is that data are not obscured by the ensemble-averaged measurements inherent in classical biochemical experiments.
A, Ishijima, T, Yanagida
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A Single-Molecule Potentiometer
Nano Letters, 2011Controlling electron transport through a single-molecule device is key to the realization of nanoscale electronic components. A design requirement for single molecule electrical devices is that the molecule must be both structurally and electrically connected to the metallic electrodes.
Jeffrey S, Meisner +5 more
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Nature Nanotechnology, 2017
Mass and electrical charge are fundamental properties of biological macromolecules. Although molecular mass has long been determined with atomic precision, a direct and precise determination of molecular charge remains an outstanding challenge. Here we report high-precision (<1e) measurements of the electrical charge of molecules such as nucleic ...
Ruggeri Francesca +7 more
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Mass and electrical charge are fundamental properties of biological macromolecules. Although molecular mass has long been determined with atomic precision, a direct and precise determination of molecular charge remains an outstanding challenge. Here we report high-precision (<1e) measurements of the electrical charge of molecules such as nucleic ...
Ruggeri Francesca +7 more
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Chemical Society Reviews, 2015
Artist impression of a single-molecule transistor, where a molecule is connected to the source and the drain electrodes. The red lines illustrated the electric field caused by the gate electrode, located below.
Mickael L. Perrin +2 more
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Artist impression of a single-molecule transistor, where a molecule is connected to the source and the drain electrodes. The red lines illustrated the electric field caused by the gate electrode, located below.
Mickael L. Perrin +2 more
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Physical Review Letters, 2004
For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography).
J C H, Spence, R B, Doak
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For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography).
J C H, Spence, R B, Doak
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Current Opinion in Structural Biology, 2003
Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of ...
Xiaowei, Zhuang, Matthias, Rief
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Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of ...
Xiaowei, Zhuang, Matthias, Rief
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2020
The dielectric nanoparties/molecules in the vicinity of a WGM microcavity evanescently perturb the WGM field. Owing to the tiny mode volume and high quality factor of the microcavity, the resulting resonance shift and spectral broadening of the microcavity’s transmission spectrum can be read out with a high enough signal-to-noise ratio.
Frank Vollmer, Deshui Yu
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The dielectric nanoparties/molecules in the vicinity of a WGM microcavity evanescently perturb the WGM field. Owing to the tiny mode volume and high quality factor of the microcavity, the resulting resonance shift and spectral broadening of the microcavity’s transmission spectrum can be read out with a high enough signal-to-noise ratio.
Frank Vollmer, Deshui Yu
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Interrogating Single Molecules
Recent Patents on Nanotechnology, 2008The development of nanotechnology relies heavily on the ability to observe and probe at molecular scales. Thus, breakthroughs in instrumentation and techniques play a significant role in the advancement in nanoscience. In this article, we survey recent developments in observing, trapping, and probing single molecules in solution.
Lin, Cong, Alexander D, Wissner-Gross
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Single-Molecule Optoelectronics
Accounts of Chemical Research, 2004With discrete states, several-atom Ag(n) nanoclusters exhibit molecule-like behavior with strong visible fluorescence and robust optical properties. This new class of single-molecule fluorophores has been created and electrically contacted in thin films to produce the first electroluminescent single molecules.
Tae-Hee, Lee +3 more
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ChemPhysChem, 2012
Single-molecule methods have developed into a mature and powerful research approach that is adding new insights into many different areas within the physical and life sciences. The ability to detect and perform experiments on single molecules opens up new experimental approaches to investigating the physical world.
Thomas, Bein +2 more
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Single-molecule methods have developed into a mature and powerful research approach that is adding new insights into many different areas within the physical and life sciences. The ability to detect and perform experiments on single molecules opens up new experimental approaches to investigating the physical world.
Thomas, Bein +2 more
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