Results 271 to 280 of about 10,475,199 (348)

Single-molecule sensing with an anthrax nanopore enabled by pH-asymmetric ionic liquids. [PDF]

J Nanobiotechnology
Zhang Z, Wang Y, Zhou S, Wang Y, Liu S, Guan X, Wang L.   +6 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Discriminating single-molecule binding events from diffraction-limited fluorescence. [PDF]

Nat Commun
Yin Y, Pathoor N, Sharma KK, Zhu S, Loh IY, Ang YS, Sim SR, Yung LYL, Wohland T, Wang L.   +9 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Triply halogen-bridged erbium compounds with hard single-molecule magnet behavior. [PDF]

Commun Chem
Chen QW, Ding YS, Huang JQ, Zhao GY, Hao Z, Zhu XF, Zheng Z.   +6 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comprehensive discovery of m⁶A sites in the human transcriptome at single-molecule resolution. [PDF]

Nat Commun
Kang G, Hwang H, Jeon H, Choi H, Chang HR, Yeo N, Park J, Son N, Jeon E, Lim J, Yun J, Choi W, Jo JY, Kim JS, Park S, Kim YK, Baek D.   +16 more
europepmc   +1 more source

Nanobiosensors for Single-Molecule Diagnostics: Toward Integration with Super-Resolution Imaging. [PDF]

Biosensors (Basel)
Lee S, Rafiq S, Kang SH.
europepmc   +1 more source

Single-molecule microtubule dynamics measurements reveal an intermediate state and clarify the role of nucleotide. [PDF]

Nat Commun
Mondal S, Bonventre E, Hancock WO, Rice LM.   +3 more
europepmc   +1 more source

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Single-Molecule Mechanoenzymatics

Annual Review of Biophysics, 2012
The ability of cellular signaling networks to sense, process, and respond to internal and external stimuli relies on their specific detection and transduction based on molecular recognition. The molecular mechanisms by which force is specifically sensed by mechanoenzymatic processes, translated into biochemical signals, and wired to cellular signaling
Elias M, Puchner, Hermann E, Gaub
openaire   +2 more sources