Results 111 to 120 of about 1,653,696 (343)

The Association Between ANKRD55 rs6859219 SNP and the Risk of Multiple Sclerosis in Iranian Patients

Caspian Journal of Neurological Sciences, 2021
Background: Multiple Sclerosis (MS) is a neuroinflammatory autoimmune disease of the central nervous system. ANKRD55 rs6859219 Single Nucleotide Polymorphisms (SNPs) are reported as a potential novel MS risk gene, but the biological reasons underlying ...
Sepideh Mandegarfard, Arash Pourgholaminejad, Seyed Mohsen Miresmaeili, Seyed Abolhassan Shahzadeh Fazeli   +3 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Joint effects of atrial fibrillation and prothrombotic genotypes on the risk of venous thromboembolism

Research and Practice in Thrombosis and Haemostasis
Background: Atrial fibrillation (AF) is a risk factor for venous thromboembolism (VTE), but the role of common prothrombotic gene variants in this relationship is unknown.
Erin Mathiesen Hald, Maja–Lisa Løchen, Kristian Hveem, Mary Cushman, Sigrid K. Brækkan, John–Bjarne Hansen   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Study of Single Nucleotide Polymorphisms in Endosomal Toll-Like Receptors-3, 7, and 9 Genes in Patients With Dengue: A Case-Control Study [PDF]

, 2021
Arvind Kumar Singh, Shantanu Prakash, Ravindra Kumar Garg, Parul Jain, Rashmi Kumar, Amita Jain   +5 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Association of C>T p757l Polymorphism in EXO1 Gene and Risk of Sporadic Colorectal Cancer in an Iranian Population

پزشکی بالینی ابن سینا, 2011
Introduction & Objective: One candidate gene for colorectal cancer susceptibility is exonuclease1 (EXO1) .It is a member of RAD2 nuclease family. It plays a main role in mismatch repair. EXO1 acts also in DNA replication and recombination.
Mahdi Montazer Haghighi, Mohammad Yaghoob Yaghoub Taleghani, Atena Irani Shemirani, Zahra Akbari, Mohsen Vahedi, Seyyed Reza Mohebi, Seyyed Reza Fatemi, Arash Jenabian, Mohammadreza Zali   +8 more
doaj  

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

SINGLE NUCLEOTIDE POLYMORPHISMS IN THE APO(A) KRINGLE IV TYPE 8 DOMAIN AND ATHEROTHROMBOTIC SERUM LIPOPROTEIN (A) CONCENTRATION, IN A PORTUGUESE PEDIATRIC POPULATION [PDF]

, 2005
Helena Ferreira Mansilha, Elı́sio Costa, Elsa F. Vieira, Ruan Pimenta, J Lourenço Gomes, José Barbot, Roseli dos Santos   +6 more
openalex   +1 more source