Results 251 to 260 of about 1,522,500 (352)

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Application of RNA-seq for single nucleotide variation identification in a cohort of patients with hypertrophic cardiomyopathy. [PDF]

Sci Rep
Chumakova A, Vlasov I, Filatova E, Klass A, Lysenko A, Salagaev G, Shadrina M, Slominsky P.   +7 more
europepmc   +1 more source

High‐Speed Raman Readout of Single Polypeptides via Plasmonic Nanopores

Advanced Materials, EarlyView.
A label‐free method is presented for single‐protein investigation using plasmonic nanopores that enable stable, cost‐effective Raman detection of polypeptides in real time. An average of 6 photons is measured during a dwell time of 7 microseconds per amino acid.
Foroogh Khozeymeh Sarbishe, Kirill Khabarov, Maria Blanco Formoso, Ilaria Micol Baldi, Veronica Storari, Henri Haka, Massimo Mastrangeli, Francesco Difato, Andrea Armirotti, Federica Villa, Francesco Tantussi, Francesco De Angelis   +11 more
wiley   +1 more source

Single nucleotide polymorphism and expression of P16 gene as a potential biomarker for oral and pre-oral cancer. [PDF]

Discov Oncol
Nigam K, Verma Y, Kulshrestha MR, Singh A, Sanyal S.   +4 more
europepmc   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

A single-nucleotide mutation of G301A in <i>GaIAA14</i> confers leaf curling in <i>Gossypium arboreum</i>. [PDF]

Front Plant Sci
Miao P, Zhang H, Xu Y, Zhang R, Hao Y, Song G, Liu J.   +6 more
europepmc   +1 more source

Bringing Attomolar Detection to the Point‐of‐Care with Nanopatterned DNA Origami Nanoantennas

Advanced Materials, EarlyView.
Single DNA molecules are captured within the hotspots of DNA origami NanoAntennas arranged on a chip surface. Fluorescence is amplified, enabling direct detection on a point‐of‐care‐compatible imaging setup (visualized as bright signals against a dark background).
Renukka Yaadav, Kateryna Trofymchuk, Mihir Dass, Vivien Behrendt, Benedikt Hauer, Jan Schütz, Cindy Close, Michael Scheckenbach, Giovanni Ferrari, Leoni Mäurer, Sophia Sebina, Viktorija Glembockyte, Tim Liedl, Philip Tinnefeld   +13 more
wiley   +1 more source

Oligonucleotide subsets selection by single nucleotide resolution barcode identification. [PDF]

Nat Commun
Kim W, Chon M, Koh Y, Choi H, Choi E, Park H, Jung Y, Ryu T, Kwon S, Choi Y.   +9 more
europepmc   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source