Results 21 to 30 of about 1,653,696 (343)

Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies

Cells, 2019
Mitochondrial genome-wide association studies identify mitochondrial single nucleotide polymorphisms (mtSNPs) that associate with disease or disease-related phenotypes.
Brendan Miller, Thalida E. Arpawong, Henry Jiao, Su-Jeong Kim, Kelvin Yen, Hemal H. Mehta, Junxiang Wan, John C. Carpten, Pinchas Cohen   +8 more
doaj   +1 more source

Assessment of possible association between rs378854 and prostate cancer risk in the Serbian population [PDF]

Archives of Biological Sciences, 2013
Prostate cancer (PCa) is the second most commonly diagnosed cancer among men worldwide. Despite its high incidence rate, the molecular basis of PCa onset and its progression remains little understood.
Brajušković G., Nikolić Zorana, Kojić A., Savić-Pavićević Dušanka, Cerović Snežana, Tomović S., Filipović Nataša, Vukotić Vinka, Romac Stanka   +8 more
doaj   +1 more source

Inferring clonal evolution of tumors from single nucleotide somatic mutations [PDF]

, 2013
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations.
Deshwar, Amit G., Jiao, Wei, Morris, Quaid, Stein, Lincoln, Vembu, Shankar   +4 more
core   +2 more sources

The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population

Frontiers in Physiology, 2018
The Aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastric cancer (GC). The overexpression of AURKA promotes inflammation and tumorigenesis in GC.
Xiaoyan Zhou, Pengli Wang, Hui Zhao
doaj   +1 more source

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population

Gut and Liver, 2018
Background/AimsThe development of nonalcoholic fatty liver disease (NAFLD) is associated with multiple genetic and environmental factors.Methods : We performed a genome-wide association study to identify the genetic factors related to NAFLD in a Korean ...
Goh Eun Chung, Young Lee, Jeong Yoon Yim, Eun Kyung Choe, Min-Sun Kwak, Jong In Yang, Boram Park, Jong-Eun Lee, Jeong A Kim, Joo Sung Kim   +9 more
doaj   +1 more source

Genomic Selection in Rubber Tree Breeding: A Comparison of Models and Methods for Managing G×E Interactions

Frontiers in Plant Science, 2019
Several genomic prediction models combining genotype × environment (G×E) interactions have recently been developed and used for genomic selection (GS) in plant breeding programs. G×E interactions reduce selection accuracy and limit genetic gains in plant
Livia M. Souza, Felipe R. Francisco, Paulo S. Gonçalves, Erivaldo J. Scaloppi Junior, Vincent Le Guen, Roberto Fritsche-Neto, Anete P. Souza, Anete P. Souza   +7 more
doaj   +1 more source

A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]

, 2012
Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian, Lawford, Bruce, Morris, Phillip, Swagell, Christopher, Voisey, Joanne, Young, Ross   +5 more
core   +2 more sources

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms [PDF]

, 2004
We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with
Aerts, Andrea, Andersson, Björn, Andersson, Leif, Bartley, Neil, Boardman, Paul E, Bovenhuis, Henk, Brandström, Mikael, Bumstead, Nat, Burt, David W, Chen, Chen, Chen, Jie, Cheng, Hans H, Consortium, International Chicken Polymorphism Map, Crooijmans, Richard P M A, Dai, Mingtao, de Koning, Dirk-Jan, Dong, Le, Dong, Wei, Ellegren, Hans, Glavina, Tijana, Gordon, Laurie, Groenen, Martien A M, Gunnarsson, Ulrika, Hao, Bailin, He, Dandan, He, Ximiao, Hillier, Ladeana W, Hocking, Paul M, Hu, Songnian, Huang, Xiangang, Huang, Yanqing, Hubbard, Simon J, Hunt, Henry, Kaiser, Pete, Kaufman, Jim, Kindlund, Ellen, Lamont, Susan J, Lan, Fengdi, Law, Andy, Li, Dawei, Li, Guangyuan, Li, Guoqing, Li, Heng, Li, Jun, Li, Ning, Li, Ruiqiang, Li, Shengting, Li, Songgang, Li, Wenjie, Li, Yuanzhe, Lin, Wei, Liu, Bin, Lucas, Susan, Meng, Qingshun, Morrice, David, Ni, Peixiang, Ovcharenko, Ivan, Overton, Ian M, Ponting, Chris, Qi, Qiuhui, Ran, Longhua, Rogers, Sally, Rothwell, Lisa, Ruan, Jue, Shi, Jianping, Stubbs, Lisa, Sun, Yongqiao, Tammi, Martti T, Tang, Haizhou, Tong, Wei, van der Poel, Jan J, van Hateren, Andy, Wahlberg, Per, Walker, Brian A, Wang, Jian, Wang, Jianjun, Wang, Jing, Wang, Jun, Wang, Miaoheng, Wang, Pei, Wang, Xiaoling, Warren, Wesley C, Webber, Caleb, Wei, Dong Qing, Wei, Ning, Wilson, Richard K, Wilson, Stuart A, Wong, Gane Ka-Shu, Xi, Yan, Xie, Fei, Yang, Huanming, Yang, Ning, Yang, Shiaw-Pyng, Yang, Xu, Yang, Zheng, Ye, Chen, Ye, Jia, Young, John R, Yu, Jun, Yu, Yingpu, Zeng, Changqing, Zhang, Jianguo, Zhang, Jingjing, Zhang, Xiaowei, Zhang, Yunze, Zhang, Zengjin, Zhang, Zhenpeng, Zhang, Zhi-Yong, Zhao, Wenming, Zhao, Yiqiang, Zheng, Hongkun, Zheng, Weimou, Zhou, Huaijun, Zhou, Jun, Zhou, Yan   +114 more
core   +3 more sources

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome [PDF]

, 2019
DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability.
Allison, Rachal M, Cooper, Tim J, Gittens, William H, Johnson, Dominic J, Neale, Matthew J, Thomas, Holly   +5 more
core   +1 more source

Functional single nucleotide polymorphism-based association studies

Human Genomics, 2006
Association studies hold great promise for the elucidation of the genetic basis of diseases. Studies based on functional single nucleotide polymorphisms (SNPs) or on linkage disequilibrium (LD) represent two main types of designs.
Carlton Victoria EH, Ireland James S, Useche Francisco, Faham Malek   +3 more
doaj   +1 more source