Results 51 to 60 of about 1,522,500 (352)

Causal associations between both psoriasis and psoriatic arthritis and multiple autoimmune diseases: a bidirectional two-sample Mendelian randomization study

Frontiers in Immunology
BackgroundNumerous observational studies have identified associations between both psoriasis (PsO) and psoriatic arthritis (PsA), and autoimmune diseases (AIDs); however, the causality of these associations remains undetermined.MethodsWe conducted a ...
Kexin Duan, Jingrui Wang, Shaomin Chen, Tong Chen, Jiajue Wang, Shujing Wang, Xinsheng Chen   +6 more
doaj   +1 more source

A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy

Frontiers in Cellular Neuroscience, 2017
Cerebral palsy (CP) is a major cause of childhood disability in developed and developing countries, but the pathogenic mechanisms of CP development remain largely unknown.
Jianhua Xu, Lei Xia, Qing Shang, Jing Du, Dengna Zhu, Dengna Zhu, Yangong Wang, Dan Bi, Juan Song, Caiyun Ma, Chao Gao, Xiaoli Zhang, Yanyan Sun, Liping Zhu, Xiaoyang Wang, Changlian Zhu, Changlian Zhu, Qinghe Xing, Qinghe Xing   +18 more
doaj   +1 more source

Single Nucleotide Polymorphism Promoter -765g/C Gen Cox-2 sebagai Faktor Risiko Terjadinya Karsinoma Kolorektal [PDF]

, 2017
Karsinoma kolorektal (KKR) merupakan keganasan yang berasal dari transformasi neoplastik sel-sel epitel kolon dan rektum, menempati urutan ketiga terbanyak dari seluruh kanker di seluruh dunia.Berbagai Perubahan DNA dapat terjadi akibat paparan dengan ...
Saleh, I. (Irsan), Triwani, T. (Triwani)
core  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

The genetic architecture of blood pressure variability: A genome‐wide association study of 9370 participants from UK Biobank

The Journal of Clinical Hypertension, 2022
Long‐term blood pressure variability (BPV) is a risk factor for cardiovascular diseases, dementia, and stroke. However, its genetic architecture is not fully understood.
Pingping Jia, Na Zhan, Baker K. K. Bat, Qi Feng, Kelvin K. F. Tsoi   +4 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +2 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Increased Risk of Clopidogrel-Induced Gastric Mucosal Erosion in Elderly Chinese Men Harboring the ABCB1 3435T Allele

Risk Management and Healthcare Policy, 2020
Lei Duan, Man Li, Fan Wang, Yulun Cai, Huiying Li, Wenli Zhou, Yuerui Li, Qiang Chen, Jing Bai, Hongbin Liu Department of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, The Second Medical Center of PLA General Hospital ...
Duan L, Li M, Wang F, Cai Y, Li H, Zhou W, Li Y, Chen Q, Bai J, Liu H   +9 more
doaj  

Association of Interleukin-10 Gene Haplotype with Gastric Cancer in a Chinese Population

Cancer Biology & Medicine, 2010
OBJECTIVE Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Previous studies have reported that IL-10 levels are signifi cantly elevated in patients with gastric cancer (GC).
Jing-yuan CUI, Hong MA, He WANG
doaj   +1 more source