Results 91 to 100 of about 2,007,382 (285)

La morphologie nominale et les segments flottants en kabyle

Multilinguales, 2020
The fact that phonological objects may be present in the lexical entry of the root but absent from the surface realization is made possible by the restricted configuration of the syllabic space: the structure does not offer enough space for all the ...
Samir Ben Si Said
doaj   +1 more source

Singularity, Wielandt’s lemma and singular values

Journal of Computational and Applied Mathematics, 2010
The authors obtain some upper and lower bounds for the largest and the smallest singular values of certain complex matrices based on the entries and diagonal dominance. A relationship between largest singular value of a block matrix and its block norm matrix is obtained. Numerical examples are given to demonstrate the usefulness of their results.
Li, Hou-Biao, Huang, Ting-Zhu, Liu, Xing-Ping, Li, Hong   +3 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Existence of positive periodic solutions for neutral Lienard differential equations with a singularity

Electronic Journal of Differential Equations, 2015
By applying Mawhin's continuation theorem, we study the existence of positive periodic solutions for a second-order neutral functional differential equation $$ ((x(t)-cx(t-\sigma)))''+f(x(t)) x'(t)+g(t,x(t-\delta))=e(t), $$ where g has a strong ...
Fanchao Kong, Shiping Lu, Zaitao Liang
doaj  

Da Psicanálise como uma ciência particular do singular

Estudos e Pesquisas em Psicologia, 2014
O artigo propõe considerarmos a psicanálise como uma ciência do singular; diferencia ciência do cientificismo contemporâneo, e define os termos “particular”, “ciência”, e “singular”.
Wanderley Magno de Carvalho
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

ON RESOLVING SINGULARITIES [PDF]

Journal of the London Mathematical Society, 2001
Let V be an irreducible affine algebraic variety over a field k of characteristic zero, and let (f_0,...,f_m) be a sequence of elements of the coordinate ring. There is probably no elementary condition on the f_i and their derivatives which determines whether the blowup of V along (f_0,...,f_m) is nonsingular. The result is that there indeed is such an
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source