Results 81 to 90 of about 2,160,503 (336)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Stratified Reduction of Singularities of Generalized Analytic Functions [PDF]
, 2022 Beatriz Molina-Samper +2 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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O Singular e o Coletivo: Por uma Política do Não-Todo
Revista Subjetividades, 2020 Este texto apresenta uma discussão em torno do tema do singular e do coletivo e traz uma proposta para pensar certo tipo de experiência coletiva fazendo um contraponto com outras formações de grupo ou de massa, como as analisadas por Freud, e também ...
Ana Cristina Costa de Figueiredo
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Singularities of the stress concentration in the presence of $C^{1,α}$-inclusions with core-shell geometry [PDF]
, 2021 Zhiwen Zhao, Hao, Xia
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Singularity, Wielandt’s lemma and singular values
Journal of Computational and Applied Mathematics, 2010 The authors obtain some upper and lower bounds for the largest and the smallest singular values of certain complex matrices based on the entries and diagonal dominance. A relationship between largest singular value of a block matrix and its block norm matrix is obtained. Numerical examples are given to demonstrate the usefulness of their results.
Li, Hou-Biao +3 more
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FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source