Results 81 to 90 of about 2,007,382 (285)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A priori bounds and existence results for singular boundary value problems
Electronic Journal of Qualitative Theory of Differential Equations, 2016 This article furnishes qualitative properties for solutions to two-point boundary value problems (BVPs) which are systems of singular, second-order, nonlinear ordinary differential equations. The right-hand side of the differential equation is allowed to
Nicholas Fewster-Young
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Existence of positive periodic solutions for higher order singular functional difference equations
Electronic Journal of Qualitative Theory of Differential Equations, 2014 We study a higher order singular functional difference equation on $\mathbb{Z}$. Sufficient conditions are obtained for the existence of at least one positive periodic solution of the equation.
Jacob Johnson +3 more
doaj +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
El singular, la práctica y la incertidumbre de la razón
Tópicos, 2013 Llano's work suggests that concepts are mere auxiliaries in the knowledge of individuals and that this knowledge is determined by the claims of some human practical activities.
Carlos Pereda
doaj +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
DAPesquisa, 2018 O artigo tem como objetivo compreender o ator em diálogo com a vida capaz de afetar e de ser afetado, da possibilidade de perceber-se anestesiado diante da produção cultural e quando necessário resistir ao que lhe é dado como ‘verdade’.
Valquiria Vasconcelos Piedade
doaj +1 more source