Results 11 to 20 of about 19,911 (192)

Properties of the strain rate sensitivity function produced by the linear viscoelasticity theory and existence of its maximum with respect to strain and strain rate

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2020
Strain rate sensitivity of stress-strain curves family generated by the Boltzmann–Volterra linear viscoelasticity constitutive equation (with an arbitrary relaxation modulus) under uni-axial loadings at constant strain rates is studied analytically as ...
Andrew Vladimirovich Khokhlov
doaj   +1 more source

The effect of non-singular term (T-stress) on mode I/III cracking parameters of brittle materials, Numerical and experimental study using different beam and disc shape specimens made of marble rock

Forces in Mechanics
This study focuses on less-studied mode I/III fracture cracking behaviour. Seven specimens (ENDC, DNDC, SCB, ENDB, ATPB, TPB-IC, and SENB) were analyzed numerically and experimentally. Results show in pure mode-I, the specimens show identical KIc values (1.22 to 1.54 MPa√m).
Amir Mousavi, M.R.M. Aliha, Hadi Khoramishad, Hamid Reza Karimi   +3 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Variation of stress intensity factor and elastic T-stress along the crack-front in finite thickness plates [PDF]

Fracture and Structural Integrity, 2009
Non-singular terms in the series expansion of the elastic crack-tip stress fields, commonly referred to as the T-stress. The T-stress is as an additional stress field characterizing parameter to stress intensity factor (K) in the analysis of cracked ...
S. K. Kudari, K. G. Kodancha
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Finite displacements in reciprocity-based FE formulation

Computer Assisted Methods in Engineering and Science, 2023
In this paper, Trefftz polynomials are used for the development of FEM based on the reciprocity relations. Such reciprocity principles are known from the Boundary Element formulations, however, using the Trefftz polynomials in the reciprocity relations ...
Vladimίr Kompiš, Pavol Novák, Marián Handrik   +2 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source