Results 61 to 70 of about 32,350 (292)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research on Multipoint Leak Location of Gas Pipeline Based on Variational Mode Decomposition and Relative Entropy

Shock and Vibration, 2020
Pipeline leak detection has always been a relatively difficult technical problem; especially in urban pipeline leak detection, there are still many problems to be solved.
Yongmei Hao, Zhanghao Du, Juncheng Jiang, ZhiXiang Xing, Xinming Yan, Shuli Wang, Yongchao Rao   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Ultrasensitive biosensing meta-garment via wetting gradient effect for heat-exhaustion warning

npj Flexible Electronics
Heat exhaustion is a prevalent heat-related illness among firefighters, posing a severe threat to life without timely intervention. However, current firefighter garments are limited by their singular functionality and cannot collect or analyze body fluid
Ming Li, Ganghua Li, Zengqing Li, Yalin Tang, Ruidong Xu, Tong Xu, Yiwen Wang, Yuanyuan Liu, Lijun Qu, Binghao Wang, Yingkui Yang, Mingwei Tian   +11 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Singular Spectrum Analysis: Methodology and Comparison [PDF]

In recent years Singular Spectrum Analysis (SSA), used as a powerful technique in time series analysis, has been developed and applied to many practical problems. In this paper, the performance of the SSA technique has been considered by applying it to a
Hassani, Hossein
core   +1 more source

Singular points detection using fingerprint orientation field reliability [PDF]

, 2010
Singular points detection is the most challenging and important process in biometrics fingerprint verification and identification systems. Singular points are used for fingerprint classification, fingerprint matching and fingerprint alignment. This paper
Alghathbar, Khaled S., Mohammad, Dzulkifli, Khalil, Mohammed Sayim, Khan, Muhammad Khurram   +3 more
core  

A Low-Complexity Model-Free Approach for Real-Time Cardiac Anomaly Detection Based on Singular Spectrum Analysis and Nonparametric Control Charts

Technologies, 2018
While the importance of continuous monitoring of electrocardiographic (ECG) or photoplethysmographic (PPG) signals to detect cardiac anomalies is generally accepted in preventative medicine, there remain numerous challenges to its widespread adoption ...
Michael Lang
doaj   +1 more source