Results 31 to 40 of about 75,343 (266)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Stress State at the Vertex of a Composite Wedge, One Side of Which Slides Without Friction Along a Rigid Surface

open access: yesLatin American Journal of Solids and Structures
For studying the stress-strain state at singular points and their neighborhoods new concept is proposed. A singular point is identified with an elementary volume that has a characteristic size of the real body representative volume.
V. Pestrenin, I. Pestrenina, L. Landik
doaj   +1 more source

Singular Points of the Tremor of the Earth’s Surface

open access: yesApplied Sciences, 2023
A method for studying properties of the Earth’s surface tremor, measured by means of GPS, is proposed. The following tremor characteristics are considered: the entropy of wavelet coefficients, the Donoho–Johnston wavelet index, and two estimates of the ...
Alexey Lyubushin
doaj   +1 more source

Walking to singular points of fingerprints

open access: yesPattern Recognition, 2016
Singular point is an essential global feature in fingerprint images. Existing methods for singular points' detection generally visit each pixel or each small image block to determine the singular point. That is to say, existing methods require scanning the image to compute a quantity at each pixel or block, and hence they are inevitably time-consuming.
En Zhu, Xifeng Guo 0001, Jianping Yin
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

When singular points determine quadratic systems

open access: yesElectronic Journal of Differential Equations, 2008
When one considers a quadratic differential system, one realizes that it depends on 12 parameters of which one can be fixed by means of a time change.
Nicolae Vulpe   +2 more
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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