Results 41 to 50 of about 75,924 (265)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Singular bielliptic curves and Weierstrass points
Le Matematiche, 1999 Here we study the Weierstrass points of singular bielliptic curves in characteristic 0. Most of our results are existence results of the type "there exists a bielliptic curve Y with certain singular points and with a weierstrass point P ∈ Y_{reg} with a ...
Edoardo Ballico
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Singular-point characterization in microscopic flows
Physical Review E, 2008 4 pages and 4 ...
Volpe, Giorgio +2 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Mathematical modeling of the process of nonlinear deformation of thin-walled structures
Вестник Дагестанского государственного технического университета: Технические наукиObjective. The objective is to develop a unified method for solving a general nonlinear boundary value problem associated with discontinuous phenomena, which allows identifying all the characteristic features of the behavior of thin-walled systems under ...
G. M. Murtazaliev, M. M. Paizulaev
doaj +1 more source
Spectral singularities of a general point interaction [PDF]
Journal of Physics A: Mathematical and Theoretical, 2011 We study the problem of locating spectral singularities of a general complex point interaction with a support at a single point. We also determine the bound states, examine the special cases where the point interaction is P-, T-, and PT-symmetric, and explore the issue of the coalescence of spectral singularities and bound states.
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source