Results 31 to 40 of about 56,216 (265)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Periodic Solutions Bifurcating From a Curve of Singularity of the Jerk System

Zanco Journal of Pure and Applied Sciences, 2020
We investigate a periodic solution which bifurcates from a curve of the singularity of the jerk system in .More precisely, we give the explicit states for the existence of a periodic solution of the jerk system with a nonisolated singular point, where ...
Niazy Hady Hussein
doaj   +3 more sources

The Second Flavor of hydrogenic atoms/ions and their applications in atomic physics, nuclear physics, and cosmology

Open Physics
We overview the second solution of the Dirac equation for hydrogen atoms that became legitimate with the allowance for the actual charge density distribution inside the protons.
Oks Eugene
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Positive Solutions of Singular Integral Equations

Journal of Integral Equations and Applications, 2000
The nonlinear singular integral equation \[ y(t)= h(t)+ \int^T_0 K(t,s)f \bigl(y(s)\bigr)ds,\;t\in\langle 0,T\rangle,\;T\in(0,+ \infty \rangle \] is considered. The Schauder fixed point theorem \((T< \infty)\) and the Schauder-Tikhonov fixed point theorem \((T=+ \infty)\) are used to establish the existence of continuous, positive solution of the ...
Meehan, Maria, O'Regan, Donal
openaire   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Behavior of positive radial solutions of a quasilinear equation with a weighted Laplacian

Electronic Journal of Differential Equations, 2001
We obtain a classification result for positive radially symmetric solutions of the semilinear equation $$ -mathop{m div}(ilde a(|x|)abla u)=ilde b(|x|)|u|^{delta-1}u, $$ on a punctured ball.
Marta Garcia-Huidobro
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source