Results 41 to 50 of about 56,216 (265)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Asymptotic behavior of singular solutions to semilinear fractional elliptic equations

Electronic Journal of Differential Equations, 2014
In this article we study the asymptotic behavior of positive singular solutions to the equation $$ (-\Delta)^{\alpha} u+u^p=0\quad\text{in } \Omega\setminus\{0\}, $$ subject to the conditions $u=0$ in $\Omega^c$ and $\lim_{x\to0}u(x)=\infty ...
Guowei Lin, Xiongjun Zheng
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A novel method for nonlinear singular oscillators

Journal of Low Frequency Noise, Vibration and Active Control, 2021
The present work deals with a study of a nonlinear singular oscillator. To approximate the frequency–amplitude relationship of the singular oscillator, reproducing kernel method is employed. The approximate solution is compared with the exact solution as
Ali Akgül, Hijaz Ahmad, Yu-Ming Chu, Phatiphat Thounthong   +3 more
doaj   +1 more source

Singularity of solutions to singular SPDEs

Building on the notes [Hai17], we give a sufficient condition for the marginal distribution of the solution of singular SPDEs on the $d$-dimensional torus to be singular with respect to the law of the Gaussian measure induced by the linearised equation.
Hairer, Martin, Kusuoka, Seiichiro, Nagoji, Hirotatsu   +2 more
openaire   +2 more sources

Approximate solution of singular integral equations

Applied Mathematics Letters, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chakrabarti, A, Berghe, Vanden G
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Positive decreasing solutions of systems of second order singular differential equations

Journal of Inequalities and Applications, 2000
Singular differential systems of the type are considered in an interval , where , , , are positive constants and , , , are positive continuous functions on .
Kusano Takaŝi, Tanigawa Tomoyuki
doaj  

On the numerical solution of the multidimensional singular integrals and integral equations, used in the theory of linear viscoelasticity

International Journal of Mathematics and Mathematical Sciences, 1988
In the present report, we investigate the formulation, for the numerical evaluation of the multidimensional singular integrals and integral equations, used in the theory of linear viscoelasticity. Some simple formulas are given for the numerical solution
E. G. Ladopoulos
doaj   +1 more source