Results 61 to 70 of about 58,847 (264)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Singular solution to Special Lagrangian Equations

Annales de l'Institut Henri Poincaré C, Analyse non linéaire, 2010
We prove the existence of non-smooth solutions to three-dimensional Special Lagrangian Equations in the non-convex case. Résumé Nous démontrons l'existence de solutions singulières d'équations speciales lagrangiennes en dimension trois, dans le cas non convexe.
Nadirashvili, Nikolai, Vlăduţ, Serge
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Bernoulli Polynomials Method for Solving Integral Equations with Singular Kernel

مجلة بغداد للعلوم
There is always an interest in an effective technique to generate a numerical solution of integral equations with singular or weakly singular kernels more precisely because numerical methods have limitations.
Muna M. Mustafa, Heba A. Abd-Alrazak
doaj   +1 more source

Uniqueness of solution of a singular heat equation

International Journal of Mathematics and Mathematical Sciences, 1984
Some uniqueness results for the singular heat equation are presented in this paper.
Eutiquio C. Young
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Self-similar singular solution of doubly singular parabolic equation with gradient absorption term

Journal of Inequalities and Applications, 2006
We deal with the self-similar singular solution of doubly singular parabolic equation with a gradient absorption term for , and in . By shooting and phase plane methods, we prove that when there exists self-similar singular solution, while there is
Shi Peihu, Wang Mingxin
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On a Singular Solution in Higgs Field

NCTAM papers, National Congress of Theoretical and Applied Mechanics, Japan, 2008
A formula for mass of Standard Model Higgs boson is derived by considering certain asymptotic behavior for singular solution of equation of motion (EOM) of Higgs field via Euler-Lagrange equation, in which M H 0 is shown as a rest mass of Higgs boson mass of the field, which maintains Lorentz invariance.
openaire   +1 more source