Results 81 to 90 of about 58,847 (264)

The Periodic Solutions of the Compound Singular Fractional Differential System with Delay

International Journal of Differential Equations, 2010
The paper gives sufficient conditions on the existence of periodic solution for a class of compound singular fractional differential systems with delay, involving Nishimoto fractional derivative.
XuTing Wei, XuanZhu Lu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

An efficient spectral method for nonlinear Volterra integro-differential equations with weakly singular kernels

Mathematical Modelling and Analysis
For Volterra integro-differential equations (VIDEs) with weakly singular kernels, their solutions are singular at the initial time. This property brings a great challenge to traditional numerical methods. Here, we investigate the numerical approximation
ZhiPeng Liu, DongYa Tao, Chao Zhang
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Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Application of the Brouwer and the Kakutani fixed-point theorems to a discrete equation with a double singular structure

Fixed Point Theory and Applications, 2018
Applying the method consisting of a combination of the Brouwer and the Kakutani fixed-point theorems to a discrete equation with a double singular structure, that is, to a discrete singular equation of which the denominator contains another discrete ...
Minoru Tabata, Nobuoki Eshima
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Existence of regular and singular bound state solutions to a quasilinear equation

Boundary Value Problems
The existence of regular and singular bound state solutions to △ p u + f ( u ) = 0 , r ∈ R n ∖ { 0 } $$ \triangle _{p}u+f(u)=0,~~~r\in \mathbb{R}^{n}\backslash \{0\} $$ is considered. Our result concerns the solution according to its behavior as r → 0 $r\
Wei-Chuan Wang
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A Progress Report on Numerical Solutions of Least Squares Adjustment in GNU Project Gama

Acta Polytechnica, 2005
GNU project Gama for adjustment of geodetic networks is presented. Numerical solution of Least Squares Adjustment in the project is based on Singular Value Decomposition (SVD) and General Orthogonalization Algorithm (GSO). Both algorithms enable solution
A. Čepek, J. Pytel
doaj