Results 41 to 50 of about 72,728 (266)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Journal of Applied Mathematics, 2012 By employing a well-known fixed point theorem, we establish the existence of multiple positive solutions for the following fourth-order singular differential equation Lu=p(t)f(t,u(t),u′′(t))-g(t,u(t),u′′(t ...
Yuefeng Han +3 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Self-similar singular solution of doubly singular parabolic equation with gradient absorption term
Journal of Inequalities and Applications, 2006 We deal with the self-similar singular solution of doubly singular parabolic equation with a gradient absorption term for , and in . By shooting and phase plane methods, we prove that when there exists self-similar singular solution, while there is
Shi Peihu, Wang Mingxin
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Fractal and FractionalIn this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang +3 more
doaj +1 more source
A fractional Kirchhoff problem involving a singular term and a critical nonlinearity
Advances in Nonlinear Analysis, 2017 In this paper, we consider the following critical nonlocal problem:
Fiscella Alessio
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Positive Solution of Singular Fractional Differential Equation in Banach Space
Journal of Applied Mathematics, 2011 We investigated a singular multipoint boundary value problem for fractional differential equation in Banach space. The nonlinear term 𝑓(𝑡,𝑥,𝑦) is positive and singular at 𝑥=𝜃 and (or) 𝑦=𝜃.
Jianxin Cao, Haibo Chen
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Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source