Results 111 to 120 of about 299,137 (271)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
ГРУППЫ СИММЕТРИЙ УРАВНЕНИЙ ПЕНЛЕВЕ
Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2012 В данной работе для 50 нелинейных ОДУ второго порядка, обладающих свойством Пенлеве, найдены однопараметрические группы симметрий и в некоторых случаях построены обшие решения.
Noshchenko, D.S., Ilyin, I.A.
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Singular World of Singular Cardinals [PDF]
, 2015 To appear in Logic Without Borders: Essays on Set Theory, Model Theory, Philosophical Logic and Philosophy of Mathematics Edited by \AA sa Hirvonen, Juha Kontinen, Roman Kossak and Andr\'es ...
openaire +4 more sources
Sudden future singularities [PDF]
Classical and Quantum Gravity, 2004 We show that a singularity can occur at a finite future time in an expanding Friedmann universe even when the density is positive and the density plus the sum of the principal pressures is positive. Explicit examples are constructed and a simple condition is given which can be used to eliminate behaviour of this sort if it is judged to be unphysical.
openaire +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Singular Reference Without Singular Thought [PDF]
Manuscrito, 2016 Abstract In this paper I challenge the widespread assumption that the conditions for singular reference are more or less the same as the conditions for singular thought. I claim that we refer singularly to things without thinking singularly about them more often than it is usually believed.
openaire +4 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source