Results 121 to 130 of about 300,939 (289)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Painleve's determinateness theorem extended to proper coverings
Electronic Journal of Differential Equations, 2010 We extend Painleve's determinateness theorem to first-order ordinary differential equations in the complex domain, with known terms allowed be multivalued in the dependent variable. The multivaluedness is supposed to be resolved by proper coverings.
Claudi Meneghin
doaj
Symplectic U7,U8 and U9 Singularities
Demonstratio Mathematica, 2015 We use the method of algebraic restrictions to classify symplectic U7, U8 and U9 singularities. We use discrete symplectic invariants to distinguish symplectic singularities of the curves.
Trębska Żaneta
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Classification of Real Solutions of the Fourth Painlevé Equation
MathematicsPainlevé transcendents are usually considered as complex functions of a complex variable, but, in applications, it is often the real cases that are of interest.
Jeremy Schiff, Michael Twiton
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Alternative Motion Control of a Parallel Mechanism With Actuation Redundancy
IEEE AccessAmong the advantages of redundantly actuated mechanisms, one can mention the higher operational robustness, the feasibility of reduced power actuators, increasing the load capacity of the mechanism.
Decio de Moura Rinaldi +1 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source