Results 111 to 120 of about 300,939 (289)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Singularities in the flying electromagnetic doughnuts
Nanophotonics, 2019 Flying doughnuts (FDs) are exact propagating solutions of Maxwell equations in the form of single-cycle, space-time non-separable toroidal pulses. Here we review their properties and reveal the existence of a complex and robust fine topological structure.
Zdagkas Apostolos +4 more
doaj +1 more source
ГРУППЫ СИММЕТРИЙ УРАВНЕНИЙ ПЕНЛЕВЕ
Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2012 В данной работе для 50 нелинейных ОДУ второго порядка, обладающих свойством Пенлеве, найдены однопараметрические группы симметрий и в некоторых случаях построены обшие решения.
Noshchenko, D.S., Ilyin, I.A.
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The Singular World of Singular Cardinals [PDF]
, 2015 To appear in Logic Without Borders: Essays on Set Theory, Model Theory, Philosophical Logic and Philosophy of Mathematics Edited by \AA sa Hirvonen, Juha Kontinen, Roman Kossak and Andr\'es ...
openaire +4 more sources
Sudden future singularities [PDF]
Classical and Quantum Gravity, 2004 We show that a singularity can occur at a finite future time in an expanding Friedmann universe even when the density is positive and the density plus the sum of the principal pressures is positive. Explicit examples are constructed and a simple condition is given which can be used to eliminate behaviour of this sort if it is judged to be unphysical.
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Singular Reference Without Singular Thought [PDF]
Manuscrito, 2016 Abstract In this paper I challenge the widespread assumption that the conditions for singular reference are more or less the same as the conditions for singular thought. I claim that we refer singularly to things without thinking singularly about them more often than it is usually believed.
openaire +4 more sources