Results 101 to 110 of about 23,028 (249)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Positive solutions for a nonlocal problem with singularity

Electronic Journal of Differential Equations, 2017
In this article we study a nonlocal problem involving singular nonlinearity. Based on the variational and perturbation methods, we obtain the existence of two positive solutions for this problem.
Chun-Yu Lei, Chang-Mu Chu, Hong-Min Suo
doaj  

Metric Singularities

Rocky Mountain Journal of Mathematics, 1999
Consider a smooth manifold \(M\) and \(g\) a smooth section of the bundle of symmetric two tensors on \(M\). A point \(p\in M\) such that \(g_p\) is degenerate is called a metric singularity. In the first part of this paper, an interesting existence and uniqueness theorem for geodesics through a metric singular point is proven (Theorem 2.6).
openaire   +3 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Analysis of spatial structure and singularity of microbial biogeochemical anomalies in the Taiwan Strait Basin

Frontiers in Marine Science
The abundance of specific hydrocarbon-oxidizing bacteria (MV value) in surface soil is closely linked to the concentration of thermogenic light hydrocarbons found in the underlying layers.
Yan Zhang, Yan Zhang, Yan Zhang, Li Zhang, Zhenyu Lei, Fan Xiao, Yongzhang Zhou, Jing Zhao, Xing Qian   +8 more
doaj   +1 more source

Singularities of frontals

Advanced Studies in Pure Mathematics, 2018
In this survey article we introduce the notion of frontals, which provides a class of generalised submanifolds with singularities but with well-defined tangent spaces. We present a review of basic theory and known studies on frontals in several geometric problems from singularity theory viewpoints.
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multiple positive solutions for singular multi-point boundary-value problem with general growth on the positive half line

Electronic Journal of Differential Equations, 2011
This work is devoted to the existence of nontrivial positive solutions for a class of second-order nonlinear multi-point boundary-value problems on the positive half-line. The novelty of this work is that the nonlinearity may exhibit a singularity at
Smail Djebali, Karima Mebarki
doaj