Results 101 to 110 of about 581,282 (341)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
ON RESOLVING SINGULARITIES [PDF]
Journal of the London Mathematical Society, 2001 Let V be an irreducible affine algebraic variety over a field k of characteristic zero, and let (f_0,...,f_m) be a sequence of elements of the coordinate ring. There is probably no elementary condition on the f_i and their derivatives which determines whether the blowup of V along (f_0,...,f_m) is nonsingular. The result is that there indeed is such an
openaire +3 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Hydrodynamic singularities [PDF]
, 2008 We give a brief overview of the physical significance of singularities in fluid mechanics.
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Electronic Journal of Differential Equations, 2011 This work is devoted to the existence of nontrivial positive solutions for a class of second-order nonlinear multi-point boundary-value problems on the positive half-line. The novelty of this work is that the nonlinearity may exhibit a singularity at
Smail Djebali, Karima Mebarki
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Acta Polytechnica, 2010 The concept of the beginning of Cosmos appears to be problematic. Not only ancient theological, but also present-day physical approaches evoke many questions. They originate in the definition of time, its dimensionality and its scale.
P. Zamarovský
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Kinematics and singularity analysis of UR5 robot
Journal of Hebei University of Science and Technology, 2019 In order to solve the problem that the UR5 robot coordinate system established by the user is inconsistent with the manufacturer's, and the data related to the force, angular velocity, angular acceleration are difficult to be directly used, based on the ...
Fuxiang ZHANG, Yang ZHAO
doaj +1 more source