Results 101 to 110 of about 295,670 (287)

Study on a kind of neutral Rayleigh equation with singularity

Boundary Value Problems, 2017
In this paper, we consider a kind of neutral Rayleigh equation with singularity, ( x ( t ) − c x ( t − δ ) ) ″ + f ( t , x ′ ( t ) ) + g ( t , x ( t ) ) = e ( t ) , $$\bigl(x(t)-cx(t-\delta)\bigr)''+f \bigl(t,x'(t)\bigr)+g\bigl(t,x(t)\bigr)=e(t ...
Yun Xin, Zhibo Cheng
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Characteristics of geological evolution based on the multifractal singularity theory: A case study of Heyu granite and Mesozoic tectonics

Open Geosciences
Tectonic movement and magmatic activity are complex geological processes resulting from the interaction of multiple factors. These processes are often characterized by local singularities with nonlinear characteristics.
Dong Wenchao, Jiang Zhongfeng, Zhang Peixin, Zhang Yuchan, Liu Leyi   +4 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Kalb-Ramond field, black holes and black strings in (2 + 1)D

Journal of High Energy Physics
New rotating dilaton black hole and black string solutions in three spacetime dimensions are obtained. The solutions are asymptotically flat and, they are exact in classical string theory. The black hole solutions have only a single horizon.
Meseret Asrat
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Bootstrapping M-theory orbifolds

Journal of High Energy Physics
We analyze correlation functions of SU(k) × SU(2) F flavor currents in a family of three-dimensional N $$ \mathcal{N} $$ = 4 superconformal field theories, combining analytic bootstrap methods with input from supersymmetric localization.
Shai M. Chester, Silviu S. Pufu, Yifan Wang, Xi Yin   +3 more
doaj   +1 more source