Results 81 to 90 of about 295,670 (287)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Invariant theory for singular α-determinants
Journal of Combinatorial Theory, Series A, 2008 26 ...
Kimoto, Kazufumi, Wakayama, Masato
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Spacelike singularities and string theory [PDF]
Classical and Quantum Gravity, 1995 An interpretation of spacelike singularities in string theory uses target space duality to relate the collapsing Schwarzschild geometry near the singularity to an inflationary cosmology in dual variables. An appealing picture thus results whereby gravitational collapse seeds the formation of a new universe.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Bogdanov-Takens Bifurcation of a Delayed Ratio-Dependent Holling-Tanner Predator Prey System
Abstract and Applied Analysis, 2013 A delayed predator prey system with refuge and constant rate harvesting is discussed by applying the normal form theory of retarded functional differential equations introduced by Faria and Magalhães.
Xia Liu, Yanwei Liu, Jinling Wang
doaj +1 more source
Deformation theory of sandwiched singularities
Duke Mathematical Journal, 1998 A sandwiched singularity is a normal surface singularity which admits a birational map to \(({\mathbb C},0)\). The paper under review is concerned with deformations of sandwiched singularities. Namely, deformations of sandwiched singularities are described via deformations of decorated curves.
Jong, T. de, Straten, D. van
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Dynamics near manifolds of equilibria of codimension one and bifurcation without parameters
Electronic Journal of Differential Equations, 2011 We investigate the breakdown of normal hyperbolicity of a manifold of equilibria of a flow. In contrast to classical bifurcation theory we assume the absence of any flow-invariant foliation at the singularity transverse to the manifold of equilibria ...
Stefan Liebscher
doaj