Results 61 to 70 of about 8,909 (266)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Quantum black holes in scalar–tensor gravity: a Green function approach
European Physical Journal C: Particles and FieldsIt is well-known that a Lagrangian resembling scalar–tensor gravity naturally emerges from string theory in the low-energy limit. This suggests that a scalar–tensor theory intrinsically inhabits precious information about quantum gravitational effects ...
Harpreet Singh, Malay K. Nandy
doaj +1 more source
Exact gravitational plane waves and two-dimensional gravity
Physics Letters B, 2018 We discuss dynamical aspects of gravitational plane waves in Einstein theory with massless scalar fields. The general analytic solution describes colliding gravitational waves with constant polarization, which interact with scalar waves and, for generic ...
Jorge G. Russo
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Positive solutions for singular $\phi-$Laplacian BVPs on the positive half-line
Electronic Journal of Qualitative Theory of Differential Equations, 2009 In this work, we are concerned with the existence of positive solutions for a $\phi$ Laplacian boundary value problem on the half-line. The results are proved using the fixed point index theory on cones of Banach spaces and the upper and lower solution ...
Smail Djebali, O. Saifi
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
T-duality across non-extremal horizons
Journal of High Energy PhysicsWhen applying T-duality to a generic, non-extreme Killing horizon, T-duality is spacelike on one side and timelike on the other. We show, using simple examples from four-dimensional Einstein-Maxwell theory, that the image of the horizon is a singularity ...
M. Médevielle, T. Mohaupt
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source