Results 61 to 70 of about 295,670 (287)

Semi-classical Approach to Charged Dilatonic Black Hole in Two Dimensions

, 1992
We consider exactly solvable semi-classical theory of two dimensional dilatonic gravity with electromagnetic interactions. As was done in the paper by Russo, Susskind and Thorlacius, the term which changes the kinetic term is added to the action.
't Hooft, Aharonov, Banks, Bilal, Callan, de Alwis, de Alwis, Hamada, Hawking, Hawking, Ichiro Oda, Ishibashi, McGuigan, Nojiri, Russo, Russo, Shin'ichi Nojiri, Susskind   +17 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Singular bifurcations and regularization theory

Physical Review E
Several nonlinear and nonequilibrium driven as well as active systems (e.g. microswimmers) show bifurcations from one state to another (for example a transition from a non motile to motile state for microswimmers) when some control parameter reaches a critical value.
Alexander Farutin, Chaouqi Misbah
openaire   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Topological singularity-induced Mott-like self-energy and its impact on Kondo cloud formation

Communications Materials
The integration of strong electron correlations into topological systems represents a rapidly evolving research direction that is significantly advancing the exploration of topological materials.
Byungkyun Kang, Zachary Brown, Myoung-Hwan Kim, Hyunsoo Kim, Chul Hong Park, Eunja Kim   +5 more
doaj   +1 more source

Position-Singularity Analysis of a Class of the 3/6-Gough-Stewart Manipulators Based on Singularity-Equivalent-Mechanism

International Journal of Advanced Robotic Systems, 2012
This paper addresses the problem of identifying the property of the singularity loci of a class of 3/6-Gough-Stewart manipulators for general orientations in which the moving platform is an equilateral triangle and the base is a semiregular hexagon ...
Hui Zhou, Yi Cao, Baokun Li, Meiping Wu, Jinghu Yu, Haiwei Chen   +5 more
doaj   +1 more source

On the stabilization of the Friedmann Big Bang by the shear stresses

, 2013
The window is found in the space of the free parameters of the theory of viscoelastic matter for which the Friedmann singularity is stable. Under stability we mean that in the presence of the shear stresses the \textit{generic} solution of the equations ...
Belinski, V. A.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Quantum black holes in scalar–tensor gravity: a Green function approach

European Physical Journal C: Particles and Fields
It is well-known that a Lagrangian resembling scalar–tensor gravity naturally emerges from string theory in the low-energy limit. This suggests that a scalar–tensor theory intrinsically inhabits precious information about quantum gravitational effects ...
Harpreet Singh, Malay K. Nandy
doaj   +1 more source