Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek +13 more
wiley +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
String Theory near a Conifold Singularity
We demonstrate that type II string theory compactified on a singular Calabi-Yau manifold is related to $c=1$ string theory compactified at the self-dual radius. We establish this result in two ways.
't Hooft +38 more
core +2 more sources
On the Existence of Meta-stable Vacua in Klebanov-Strassler [PDF]
We solve for the complete space of linearized deformations of the Klebanov-Strassler background consistent with the symmetries preserved by a stack of anti-D3 branes smeared on the $S^3$ of the deformed conifold.
A Butti +30 more
core +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Finite-Temperature Fractional D2-Branes and the Deconfinement Transition in 2+1 Dimensions
The supergravity dual to N regular and M fractional D2-branes on the cone over \mathbb{CP}^3 has a naked singularity in the infrared. One can resolve this singularity and obtain a regular fractional D2-brane solution dual to a confining 2+1 dimensional N
A Buchel +42 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Supersymmetric backgrounds in (1 + 1) dimensions and inhomogeneous field theory
We find a (1 + 1)-dimensional metric solution for a background hosting various supersymmetric field theories with a single non-chiral real supercharge. This supersymmetric background is globally hyperbolic even though it contains a naked null singularity.
Jeongwon Ho +3 more
doaj +1 more source
The semi-classical expansion and resurgence in gauge theories: new perturbative, instanton, bion, and renormalon effects [PDF]
We study the dynamics of four dimensional gauge theories with adjoint fermions for all gauge groups, both in perturbation theory and non-perturbatively, by using circle compactification with periodic boundary conditions for the fermions.
A Armoni +69 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source

