Results 31 to 40 of about 8,909 (266)

Singularity property and singularity-free path planning of the Gough–Stewart parallel mechanism

open access: yesInternational Journal of Advanced Robotic Systems, 2017
Singularity affects the performance of the parallel mechanisms seriously and so should be avoided as the mechanisms work. It is necessary to obtain the distribution of the singularity locus in the task space of a parallel mechanism and then further ...
Baokun Li   +5 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Condensates and singularities in string theory [PDF]

open access: yesNuclear Physics B, 1994
We derive a class of solutions to the string sigma-model equations for the closed bosonic string. The tachyon field is taken to form a constant condensate and the beta-function equations at one-loop level are solved for the evolution of the metric and the dilaton. The solutions represent critical string theories in arbitrary dimensions. The spectrum of
Kostelecký, V. Alan, Perry, Malcolm J.
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Singularity theory in classical cosmology [PDF]

open access: yesIl Nuovo Cimento B Series 11, 1992
This paper compares recent approaches appearing in the literature on the singularity problem for space-times with nonvanishing torsion.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Black hole solutions in mimetic Born-Infeld gravity

open access: yesEuropean Physical Journal C: Particles and Fields, 2018
The vacuum, static, and spherically symmetric solutions in the mimetic Born-Infeld gravity are studied. The mimetic Born-Infeld gravity is a reformulation of the Eddington-inspired-Born-Infeld (EiBI) model under the mimetic approach.
Che-Yu Chen   +2 more
doaj   +1 more source

Supersymmetric backgrounds in (1 + 1) dimensions and inhomogeneous field theory

open access: yesJournal of High Energy Physics, 2023
We find a (1 + 1)-dimensional metric solution for a background hosting various supersymmetric field theories with a single non-chiral real supercharge. This supersymmetric background is globally hyperbolic even though it contains a naked null singularity.
Jeongwon Ho   +3 more
doaj   +1 more source

Spacelike singularities and string theory [PDF]

open access: yesClassical and Quantum Gravity, 1995
An interpretation of spacelike singularities in string theory uses target space duality to relate the collapsing Schwarzschild geometry near the singularity to an inflationary cosmology in dual variables. An appealing picture thus results whereby gravitational collapse seeds the formation of a new universe.
openaire   +2 more sources

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