Results 121 to 130 of about 72,352 (232)

Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

JCI Insight, 2022
Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP.
Lu Ren, Phung N. Thai, Raghavender Reddy Gopireddy, Valeriy Timofeyev, Hannah A. Ledford, Ryan L. Woltz, Seojin Park, Jose L. Puglisi, Claudia M. Moreno, Luis Fernando Santana, Alana C. Conti, Michael I. Kotlikoff, Yang Kevin Xiang, Vladimir Yarov-Yarovoy, Manuela Zaccolo, Xiao-Dong Zhang, Ebenezer N. Yamoah, Manuel F. Navedo, Nipavan Chiamvimonvat   +18 more
doaj   +1 more source

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart

Frontiers in Physiology, 2020
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults.
Aaazh M. Alghamdi, Aaazh M. Alghamdi, Mark R. Boyett, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang   +7 more
doaj   +1 more source

Right‐sided vagus nerve stimulation: Worldwide collection and perspectives

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 565-576, March 2025.
Abstract Objective Vagus nerve stimulation (VNS) is an established therapy for drug‐resistant epilepsy (DRE) and is indicated for implantation on the left vagus nerve‐only. In rare cases right‐sided VNS may be the only option. With only seven published cases in the literature, data on safety and effectiveness of right‐sided VNS is very limited ...
Marc Zanello, Berthold Voges, Ramesh Chelvarajah, Arjune Sen, Željka Petelin Gadže, Guillaume Penchet, Alessandro De Benedictis, Riccardo Fornaro, Masaki Iwasaki, Keiya Iijima, Elena Jiltsova, Goran Mrak, Sami Barrit, Alessandro Moiraghi, Andrea Landi, Marcus Neale, Shailendra Magdum, François Caire, Bertrand Godet, Philippe Domenech, Raphael Gaillard, Marc Guenot, Jason Labuschagne, Alexandre Rainha Campos, Herbert Rooijakkers, Riëm El Tahry, Tatiana Von Hertwig Fernandes De Oliveira, Amelia Alvarez‐Sala, Cristina V. Torres, Fernando Vale, Johan Pallud, Romain Carron   +31 more
wiley   +1 more source

Desynchronization in heterogeneous networks due to uniform exposure [PDF]

arXiv, 2018
We study synchronization and rhythmic patterns generated in the heterogeneous cluster of FitzHugh$-$Nagumo oscillators with transition between self-oscillating and excitable elements. Such cluster models the sinoatrial node of the heart, and the particular point of focus is the role of different physiological responses to mechanical stress: stretch ...
arxiv  

Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center

Pediatric Discovery, Volume 3, Issue 1, March 2025.
Endocardial TP have shown remarkable efficacy in the treatment of critical heart disease, especially fulminant myocarditis. Abstract Endocardial temporary pacemakers (TP) are widely used in the treatment of cardiovascular diseases in adults, but their application and clinical experience in the treatment of pediatric cardiovascular cases are relatively ...
Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang   +5 more
wiley   +1 more source

CAROTID ARTERY STENTING IN A PATIENT WITH SINUS BRADYCARDIA: CLINICAL CASE

Рациональная фармакотерапия в кардиологии, 2018
Syndrome of hemodynamic depression is a frequent complication of the carotid artery endovascular intervention and, as a rule, is transient in nature. This article presents a clinical case of carotid artery stenting in a 63-year-old patient.
E. S. Bulgakova, T. V. Tvorogova, B. A. Rudenko, O. M. Drapkina   +3 more
doaj   +1 more source

Cell-based Biological Pacemakers: Progress and Problems [PDF]

, 2018
The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases.
Ito, Hiroshi, Nakamura, Kazufumi, Saito, Yukihiro   +2 more
core   +1 more source

Effects of Age, Sex, and Exercise on Measurement of Serum CTnI Levels and Some Parameters Related to the Cardiovascular Capacity of Caspian Horses

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
The results of this study reveal for the first time that the normal average of serum cTnI, packed cell volume (PCV), and blood haemoglobin (Hb) levels in Caspian horses are 2.5 ng/L, 35.52%, and 12.1%, respectively. Furthermore, the findings indicate that exercise significantly increases serum levels of cTnI, PCV, and blood haemoglobin; however, age ...
Hossein Mehrazin, Mehdi Sakha, Shahabeddin Safi   +2 more
wiley   +1 more source

Cellular Mechanisms of Sinus Node Dysfunction in Carriers of the SCN5A-E161K Mutation and Role of the H558R Polymorphism

Frontiers in Physiology, 2018
Background: Carriers of the E161K mutation in the SCN5A gene, encoding the NaV1.5 pore-forming α-subunit of the ion channel carrying the fast sodium current (INa), show sinus bradycardia and occasional exit block.
Ronald Wilders
doaj   +1 more source

Causal Scale Shift Associated with Phase Transition to Human Atrial Fibrillation [PDF]

arXiv, 2018
An example of phase transition in natural complex systems is the qualitative and sudden change in the heart rhythm between sinus rhythm and atrial fibrillation (AF), the most common irregular heart rhythm in humans. While the system behavior is centrally controlled by the behavior of the sinoatrial node in sinus rhythm, the macro-scale collective ...
arxiv