Results 111 to 120 of about 10,507 (197)

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function [PDF]

, 2017
Background: Guanylyl cyclase, a heme-containing alpha 1 beta 1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO-GC1-cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac ...
Beuve, Annie, Brouckaert, Peter, Crassous, Pierre-Antoine, Gordan, Richard, Huang, Can, Lampe, Paul D, Shu, Ping, Xie, Lai-Hua   +7 more
core   +2 more sources

Generation of an iPSC cell line (VANYHHi001-A) from a patient with cardiac arrythmias carrying CACNA1D, SCN5A, and DSP variants

Stem Cell Research
Progressive cardiac conduction defect often associated with variants in sodium voltage-gated channel SCN5A gene and variants in the L-type calcium voltage-gated channel CACNA1D gene are implicated in sinoatrial node dysfunction.
Yvonne Sleiman, Jean-Baptiste Reisqs, Reina Bianca Tan, Frank Cecchin, Mohamed Chahine, Mohamed Boutjdir   +5 more
doaj   +1 more source

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

Frontiers in Physiology, 2014
Normal heart rhythm (sinus rhythm) depends on regular activity of the sinoatrial node (SAN), a heterogeneous collection of specialized myocytes in the right atrium.
Sathya D Unudurthi, Roseanne M Wolf, Thomas eHund, Thomas eHund   +3 more
doaj   +1 more source

Anesthetizing the Fibrillating Heart. [PDF]

, 2019
See Article Lee et ...
Hanna, Peter, Rajendran, Pradeep S, Shivkumar, Kalyanam, Zhu, Ching   +3 more
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Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review

Frontiers in Cardiovascular Medicine
Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial ...
Xinxin Shi, Xinxin Shi, Liming He, Liming He, Yucheng Wang, Yucheng Wang, Yue Wu, Yue Wu, Dongming Lin, Chao Chen, Ming Yang, Shuwei Huang, Shuwei Huang   +12 more
doaj   +1 more source

Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction

Frontiers in Cardiovascular Medicine
IntroductionLithium is a well-known agent to cause systemic toxicity with its narrow therapeutic window. Toxic cardiac effects are known but seldomly reported and can manifest as sinus node dysfunction (SND) ranging from delayed conduction to sinus ...
J. Curran Henson, Lauren Morehead, Joshua Hagood, Niroshi Wijewardane, Hakan Paydak   +4 more
doaj   +1 more source

Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart

Frontiers in Physiology, 2019
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in the
Yu Zhang, Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski   +11 more
doaj   +1 more source

The role of CaMKII-dependent augmented INa,L in arrhythmias during acute β-adrenergic stimulation [PDF]

, 2018
The heart has evolved elaborate pathways for adapting function to acute stress stimuli [e.g. sympathetic stimulation of β-adrenergic receptors (β-ARs)].
Lane, Cemantha
core  

The electrophysiological effects of Tongyang Huoxue granules on the ignition phase during hypoxia/reoxygenation injury in sinoatrial node cells

Frontiers in Physiology
IntroductionThis study was undertaken to explore the potential therapeutic effects of Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac disorder characterized by impaired impulse generation or conduction.
Qiaomin Wu, Xing Chang, Yanli Wang, Jinfeng Liu, Xuanke Guan, Zhiming Liu, Ruxiu Liu   +6 more
doaj   +1 more source