Results 91 to 100 of about 972,180 (179)

Generation of an iPSC cell line (VANYHHi001-A) from a patient with cardiac arrythmias carrying CACNA1D, SCN5A, and DSP variants

Stem Cell Research
Progressive cardiac conduction defect often associated with variants in sodium voltage-gated channel SCN5A gene and variants in the L-type calcium voltage-gated channel CACNA1D gene are implicated in sinoatrial node dysfunction.
Yvonne Sleiman, Jean-Baptiste Reisqs, Reina Bianca Tan, Frank Cecchin, Mohamed Chahine, Mohamed Boutjdir   +5 more
doaj   +1 more source

Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure

SUMMARY Heart failure (HF) affects approximately 6.2 million people in the United States, with a 5-year mortality exceeding 50%. Bradyarrhythmia, a known complication in HF due to sinoatrial node (SAN) dysfunction (SAND), increases the morbidity and mortality of HF patients. Insights into the mechanistic underpinnings
Ren, Lu, Liu, Yu, Zhang, Hao, Diloretto, Daphne A., Zheng, Yang, Caudal, Arianne, Xie, Mengjie, Zeng, Wenshu, Woltz, Ryan L., Shin, Hye Sook, Ngo, Richard Q., Perkins, Guy A., Grigorean, Gabriela, Yamoah, Ebenezer N., Wu, Joseph C., Chiamvimonvat, Nipavan, Thai, Phung N.   +16 more
openaire   +2 more sources

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes [PDF]

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
Muriel Nobles, Sonia Sebastian, Tinker, A., Andrew Tinker, Nobles, M., Sebastian, S., Nobles, Muriel   +6 more
core   +1 more source

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

Frontiers in Physiology, 2014
Normal heart rhythm (sinus rhythm) depends on regular activity of the sinoatrial node (SAN), a heterogeneous collection of specialized myocytes in the right atrium.
Sathya D Unudurthi, Roseanne M Wolf, Thomas eHund, Thomas eHund   +3 more
doaj   +1 more source

Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review

Frontiers in Cardiovascular Medicine
Sick sinus syndrome (SSS) is a grave medical condition that can precipitate sudden death. The pathogenesis of SSS remains incompletely understood. Existing research postulates that the fundamental mechanism involves increased fibrosis of the sinoatrial ...
Xinxin Shi, Xinxin Shi, Liming He, Liming He, Yucheng Wang, Yucheng Wang, Yue Wu, Yue Wu, Dongming Lin, Chao Chen, Ming Yang, Shuwei Huang, Shuwei Huang   +12 more
doaj   +1 more source

Functional and morphological organization of the cat sinoatrial node

, 1986
The feline sinoatrial node has a unifocal impulse generation as previously described for rodents. Its main component is collagen. The primary pacemaker consists of at most 2000 cells, but appears to function normally with less than 500 cells.
Jongsma, H. J., Bouman, L. N., de Jonge, B., Masson-Pevet, M., Opthof, T.   +4 more
core   +1 more source

Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction

Frontiers in Cardiovascular Medicine
IntroductionLithium is a well-known agent to cause systemic toxicity with its narrow therapeutic window. Toxic cardiac effects are known but seldomly reported and can manifest as sinus node dysfunction (SND) ranging from delayed conduction to sinus ...
J. Curran Henson, Lauren Morehead, Joshua Hagood, Niroshi Wijewardane, Hakan Paydak   +4 more
doaj   +1 more source

Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart

Frontiers in Physiology, 2019
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in the
Yu Zhang, Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski   +11 more
doaj   +1 more source

The Evolution of Sinoatrial Node Function in Man [PDF]

, 1973
The function of the sinoatrial node is complex. In nearly all hearts, this small bit of tissue is responsible for spontaneously generating the impulse which will be distributed to the remainder of the heart, maintaining coordinated electrical and ...
Strauss, Harold C., Bigger, J. Thomas
core  

Loss of Natriuretic Peptide Receptor C Enhances Sinoatrial Node Dysfunction in Aging and Frail Mice. [PDF]

J Gerontol A Biol Sci Med Sci, 2022
Jansen HJ, Moghtadaei M, Rafferty SA, Belke DD, Rose RA.   +4 more
europepmc   +1 more source